{"classes":[{"categories":[{"measurements":[{"comment":"No participants in this age group.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"No participants in this age group.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"Due to insufficient number of participants in this age group (only 1 participant), CV% could not be calculated.","groupId":"OG002","spread":"NA","value":"30.6"},{"comment":"Due to insufficient number of participants in this age group (only 1 participant), CV% could not be calculated.","groupId":"OG003","spread":"NA","value":"53.8"}]}],"title":"Infants and Toddlers (age>2yr; n=0; n=0; n=1; n=1)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"61.8","value":"110.6"},{"groupId":"OG001","spread":"80.2","value":"142.5"},{"groupId":"OG002","spread":"82.6","value":"111.2"},{"groupId":"OG003","spread":"78.5","value":"208.4"}]}],"title":"Children (age>=2 & <12yr; n=11; n=16; n=9; n=7)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"50.6","value":"92.6"},{"groupId":"OG001","spread":"73.0","value":"116.5"},{"groupId":"OG002","spread":"59.0","value":"235.1"},{"groupId":"OG003","spread":"68.3","value":"123.3"}]}],"title":"Adolescents (age>=12; n=9; n=8; n=9; n=2)"},{"categories":[{"measurements":[{"comment":"No participants in this age group.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"Due to insufficient number of participants in this age group (only 1 participant), CV% could not be calculated.","groupId":"OG001","spread":"NA","value":"143.2"},{"comment":"No participants in this age group.","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"No participants in this age group.","groupId":"OG003","spread":"NA","value":"NA"}]}],"title":"Above 18 years (n=0; n=1; n=0; n=0)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"58.0","value":"102.1"},{"groupId":"OG001","spread":"77.6","value":"133.6"},{"groupId":"OG002","spread":"75.0","value":"148.1"},{"groupId":"OG003","spread":"87.6","value":"163.9"}]}],"title":"Total"}],"denoms":[{"counts":[{"groupId":"OG000","value":"20"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"19"},{"groupId":"OG003","value":"10"}],"units":"Participants"}],"description":"PK is the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body. Cmax is the maximum observed concentration of drug substance in plasma.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Dasatinib 60 mg/m\\^2 QD, as long as clinical benefit was maintained.","id":"OG000","title":"Dasatinib 60 mg/m^2"},{"description":"Tablets, Oral; If necessary in participants who could not swallow, tablets were dispersed into 30 cc of 100% fruit juice with no preservatives (minute maid lemonade or orange juice or apple juice). Dasatinib 80 mg/m\\^2 QD, as long as clinical benefit was maintained.","id":"OG001","title":"Dasatinib 80 mg/m^2"},{"description":"Tablets, Oral; If necessary in participants who could not swallow, tablets were dispersed into 30 cc of 100% fruit juice with no preservatives (minute maid lemonade or orange juice or apple juice). Dasatinib 100 mg/m\\^2 QD, as long as clinical benefit was maintained.","id":"OG002","title":"Dasatinib 100 mg/m^2"},{"description":"Tablets, Oral; If necessary in participants who could not swallow, tablets were dispersed into 30 cc of 100% fruit juice with no preservatives (minute maid lemonade or orange juice or apple juice). Dasatinib 120 mg/m\\^2 QD, as long as clinical benefit was maintained.","id":"OG003","title":"Dasatinib 120 mg/m^2"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"All treated participants with plasma samples available. Each participant could have 1, 2, or 3 plasma PK profiles sampled, depending on the number of times the dose of dasatinib was escalated. n=number of PK parameters included.","reportingStatus":"POSTED","timeFrame":"During Week 1 of Course 1, and any course in which dose escalation was performed (at pre-dose, and at 0.5, 1, 2, 4, 6, 8 and 24 hours).","title":"Dasatinib Plasma Pharmacokinetic Parameter: Observed Maximum Plasma Concentration (Cmax) by Dose Level and Age Group","type":"SECONDARY","unitOfMeasure":"ng/mL"}