{"analyses":[{"groupDescription":"A mixed effects model was run with NCF Composite Score (baseline, 10, 22, 46 weeks) as the outcome of interest. Treatment arm, recursive partitioning analysis (RPA) class, MGMT status, and time were included in the model. Treatment arm is reported here.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.2357","statisticalComment":"Each explanatory variable is reported separately. (Time and intercept effects are not shown.)","statisticalMethod":"Mixed Models Analysis"},{"groupDescription":"A mixed effects model was run with NCF Composite Score (baseline, 10, 22, 46 weeks) as the outcome of interest. Treatment arm, recursive partitioning analysis (RPA) class, MGMT status, and time were included in the model. RPA is reported here.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.0147","statisticalComment":"Each explanatory variable is reported separately. (Time and intercept effects are not shown.)","statisticalMethod":"Mixed Models Analysis"},{"groupDescription":"A mixed effects model was run with NCF Composite Score (baseline, 10, 22, 46 weeks) as the outcome of interest. Treatment arm, recursive partitioning analysis (RPA) class, MGMT status, and time were included in the model. MGMT Status is reported here.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.457","statisticalComment":"Each explanatory variable is reported separately. (Time and intercept effects are not shown.)","statisticalMethod":"Mixed Models Analysis"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.6","upperLimit":"-0.9","value":"-1.2"},{"groupId":"OG001","lowerLimit":"-1.8","upperLimit":"-1.1","value":"-1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"80"},{"groupId":"OG001","value":"85"}],"units":"Participants"}],"title":"Baseline"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.7","upperLimit":"-1.0","value":"-1.3"},{"groupId":"OG001","lowerLimit":"-1.9","upperLimit":"-1.0","value":"-1.45"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"67"},{"groupId":"OG001","value":"63"}],"units":"Participants"}],"title":"Week 10 (Cycle 1)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.6","upperLimit":"-0.6","value":"-1.1"},{"groupId":"OG001","lowerLimit":"-2.0","upperLimit":"-0.6","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"39"},{"groupId":"OG001","value":"35"}],"units":"Participants"}],"title":"Week 22 (Cycle 4)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-2.1","upperLimit":"0.2","value":"-1.0"},{"groupId":"OG001","lowerLimit":"-2.0","upperLimit":"-0.3","value":"-1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"20"}],"units":"Participants"}],"title":"Week 46 (Cycle 10)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"95"}],"units":"Participants"}],"description":"The NCF Composite score is the arithmetic mean of the HVLT-R (Free Recall, Delayed Recall, Delayed Recognition), TMTA, TMTB, and COWA scores, all of which are standardized, adjusting for age, education, and gender as necessary, such that mean is 0 and standard deviation is 1. A participant must have at least 5 of the 6 scores. A higher composite score indicates better neurocognitive function.","dispersionType":"95% Confidence Interval","groups":[{"description":"Concurrent radiation therapy with concurrent temozolomide (75 mg/m2) up to 49 doses. Starting four weeks after completion of RT, 100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle for 6 cycles, up to 12 cycles.","id":"OG000","title":"Conventional Adjuvant TMZ"},{"description":"Concurrent radiation therapy (RT) with concurrent temozolomide (75 mg/m2) up to 49 doses. Starting four weeks after completion of RT, 75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle for 6 cycles, up to 12 cycles.","id":"OG001","title":"Dose-dense Adjuvant TMZ"}],"paramType":"MEAN","populationDescription":"Questionnaires were not completed by all QOL population participants. Therefore, the number of participants reported below are the number with data at baseline and the given time point on each arm.","reportingStatus":"POSTED","timeFrame":"Baseline, 10, 22, and 46 weeks","title":"Mean Neurocognitive Function (NCF) Composite Score Over Time","type":"SECONDARY","unitOfMeasure":"score on a scale"}