{"analyses":[{"groupDescription":"A Cox proportional hazards model was run with overall survival as the outcome of interest and baseline scores as continuous covariates. The final model was determined from stepwise selection. EORTC physical functioning, EORTC role functioning, standardized HVLT-R recognition, standardized HVLT-R recall, and standardized COWA were included in the initial model. EORTC physical functioning is reported here.","groupIds":["OG000"],"nonInferiorityType":"OTHER","pValue":"0.023","statisticalMethod":"Regression, Cox"},{"groupDescription":"A Cox proportional hazards model was run with overall survival as the outcome of interest and baseline scores as continuous covariates. The final model was determined from stepwise selection. EORTC physical functioning, EORTC role functioning, standardized HVLT-R recognition, standardized HVLT-R recall, and standardized COWA were included in the initial model. Standardized HVLT-R recognition is reported here.","groupIds":["OG000"],"nonInferiorityType":"OTHER","pValue":"0.043","statisticalMethod":"Regression, Cox"},{"groupDescription":"A Cox proportional hazards model was run with overall survival as the outcome of interest and baseline scores as continuous covariates. The final model was determined from stepwise selection. EORTC physical functioning, EORTC role functioning, standardized HVLT-R recognition, standardized HVLT-R recall, and standardized COWA were included in the initial model. Standardized COWA is reported here.","groupIds":["OG000"],"nonInferiorityType":"OTHER","pValue":"0.021","statisticalMethod":"Regression, Cox"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"14.0","upperLimit":"20.9","value":"17.5"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"154"}],"units":"Participants"}],"description":"Overall survival time is defined as time from registration/randomization to the date of death from any cause or last known follow-up (censored). Overall survival rates are estimated by the Kaplan-Meier method. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire \\[EORTC QLQ\\]-C30 subscales are calculated as the mean of component items, then standardized such that subscale scores range from 0 to 100. A high score for a functional scale represents a healthy level of functioning. Controlled Oral Word Association (COWA) score is the sum of correct responses with a range of 0 to infinity. A higher score indicates better functioning. Hopkins Verbal Learning Test - Revised (HVLT-R) score ranges from 0 to 36 for total recall is 0 to 36, 0 to 12 for delayed recall, and -12 to 12 for recognition. A higher score indicates better functioning.","dispersionType":"95% Confidence Interval","groups":[{"description":"Concurrent radiation therapy with concurrent temozolomide (75 mg/m2) up to 49 doses. Starting four weeks after completion of RT, either \\[100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle\\] or \\[75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle\\] for 6 cycles, up to 12 cycles.","id":"OG000","title":"Both Arms Combined"}],"paramType":"MEDIAN","populationDescription":"Both arms are combined per the protocol. Questionnaires/assessments were not completed by all QOL population participants. Therefore, only 154/191 have COWA, EORTC QLQ-C30, and HVLT-R baseline assessments (final model covariates)","reportingStatus":"POSTED","timeFrame":"From randomization to last follow-up. Maximum follow-up at time of analysis was 4.4 years.","title":"Determination of Impactful Baseline Instruments on Overall Survival","type":"SECONDARY","unitOfMeasure":"months"}