{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"}]}],"title":"Complete Remission"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Partial Remission"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"3"}]}],"title":"Hematologic Improvement"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Clinical Benefit"}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"16"},{"groupId":"OG002","value":"16"}],"units":"Participants"}],"description":"Complete Remission (CR): Normalization of the peripheral blood and bone marrow with \\<5% bone marrow blasts, a peripheral blood granulocyte count \\> (1.0 x 109/ L, and a platelet count \\> 100 x 109/L).\n\nPartial Remission: as above except for the presence of 6-15% marrow blasts, or 50% reduction if \\<15% at start of treatment.\n\nHematologic Improvement: meets all criteria for CR except for platelet recovery to \\>100 x 109/L.\n\nClinical Benefit: Platelets increase by 50% and to above 30 x 109/L untransfused (if lower than that pretherapy); or granulocytes increase by 100% and to above 109/L (if lower than that pretherapy); or hemoglobin increase by 2 g/dl; or transfusion independent; or splenomegaly reduction by \\> 50%; or monocytosis reduction by \\> 50% if pretreatment \\> 5 x 109/L.","groups":[{"description":"Original dose of 40 mg oral reduced to 30mg and than lower dose of either 10 mg (Group 1) or 20 mg (Group 2) tablets once a day for 5 days in a row and repeated every 4-8 week cycle.","id":"OG000","title":"Oral Clofarabine"},{"description":"Arm A: 10 mg tablets once a day for 5 days in a row and repeated every 4-8 week cycle.","id":"OG001","title":"Randomized, Oral Clofarabine 10mg"},{"description":"Arm B: 20 mg tablets once a day for 5 days in a row and repeated every 4-8 week cycle.","id":"OG002","title":"Randomized, Oral Clofarabine 20mg"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"After 3 courses of treatment, up to 24 weeks.","title":"Participants With a Complete Remission (CR)","type":"PRIMARY","unitOfMeasure":"Participants"}