{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"69.20","value":"-14.2"},{"groupId":"OG001","spread":"64.41","value":"-42.5"},{"groupId":"OG002","spread":"66.52","value":"-31.5"}]}],"title":"Week 24 [N=172, 166, 170]"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"55.08","value":"-37.1"},{"groupId":"OG001","spread":"62.74","value":"-50.2"},{"groupId":"OG002","spread":"62.64","value":"-45.1"}]}],"title":"Week 48 [N=172, 166, 170]"}],"denoms":[{"counts":[{"groupId":"OG000","value":"172"},{"groupId":"OG001","value":"167"},{"groupId":"OG002","value":"170"}],"units":"Participants"}],"description":"Sixty-eight joints were assessed and classified as tender/not tender by pressure and joint manipulation on physical examination.\n\nThe percentage change from baseline at each post-baseline visit was calculated as:\n\n\\[(post-baseline value minus baseline value) divided by Baseline value\\]\\*100.\n\nA negative percentage change from baseline score indicates an improvement.","dispersionType":"Standard Deviation","groups":[{"description":"Participants received placebo intravenous infusion on Days 1 and 15. From Week 16 onwards, participants could switch to receive rituximab 0.5 g (on Days 1 and 15) every 24 weeks for up to 5 years if they were not in clinical remission and safety criteria were met. Placebo and rituximab infusions were preceded with 100 mg intravenous methylprednisolone. Participants also received a stable dose of 10-25 mg/week of MTX and ≥ 5 mg/week folic acid for the duration of their participation in the study.\n\nAll participants entered a 48-week safety follow-up (SFU) period following the treatment period.","id":"OG000","title":"Placebo + MTX"},{"description":"Participants received 0.5 g rituximab administered by intravenous infusion on Days 1 and 15. After Week 24, participants received further courses of rituximab every 24 weeks for up to 5 years if they were not in clinical remission and safety criteria were met. Rituximab infusions were preceded with 100 mg intravenous methylprednisolone.\n\nParticipants also received a stable dose of 10-25 mg/week of methotrexate and ≥ 5 mg/week folic acid for the duration of their participation in the study.\n\nAll participants entered a 48-week safety follow-up (SFU) period following the treatment period.","id":"OG001","title":"Rituximab 2 x 0.5 g + MTX"},{"description":"Participants received 1.0 g rituximab administered by intravenous infusion on Days 1 and 15. After Week 24, participants received further courses of rituximab every 24 weeks for up to 5 years if they were not in clinical remission and safety criteria were met. Rituximab infusions were preceded with 100 mg intravenous methylprednisolone.\n\nParticipants also received a stable dose of 10-25 mg/week of methotrexate and ≥ 5 mg/week folic acid for the duration of their participation in the study.\n\nAll participants entered a 48-week safety follow-up (SFU) period following the treatment period.","id":"OG002","title":"Rituximab 2 x 1.0 g + MTX"}],"paramType":"MEAN","populationDescription":"Intent-to-treat population, LOCF was used. \"N\" indicates the number of participants with non-missing data at each time point.","reportingStatus":"POSTED","timeFrame":"Baseline, Week 24 and Week 48","title":"Percent Change From Baseline in Tender Joint Count","type":"SECONDARY","unitOfMeasure":"percent change"}