{"analyses":[{"ciLowerLimit":"0.12","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.75","estimateComment":"Reference level = low","groupDescription":"Progression-free survival is compared between low and high SUVmax groups.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.01","paramType":"Hazard Ratio (HR)","paramValue":"0.30","statisticalComment":"2-sided significance level = 0.05","statisticalMethod":"Log Rank"},{"ciLowerLimit":"0.12","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.20","estimateComment":"Reference level = low","groupDescription":"Overall survival (OS) is compared between low and high SUVmax groups.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.10","paramType":"Hazard Ratio (HR)","paramValue":"0.38","statisticalComment":"2-sided significance level = 0.05","statisticalMethod":"Log Rank"},{"ciLowerLimit":"0.10","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.97","estimateComment":"Reference level = low","groupDescription":"Loco-regional control (LRC) is compared between low and high SUVmax groups.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.04","paramType":"Hazard Ratio (HR)","paramValue":"0.31","statisticalComment":"2-sided significance level = 0.05","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"37.8","upperLimit":"70.6","value":"55.9"},{"groupId":"OG001","lowerLimit":"68.2","upperLimit":"93.6","value":"85.3"}]}],"title":"Progression-free Survival (PFS)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"68.2","upperLimit":"93.6","value":"85.3"},{"groupId":"OG001","lowerLimit":"75.1","upperLimit":"97.1","value":"91.2"}]}],"title":"Overall Survival (OS)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"17.4","upperLimit":"48.3","value":"32.4"},{"groupId":"OG001","lowerLimit":"3.6","upperLimit":"25.1","value":"11.8"}]}],"title":"Loco-regional failure (LRF)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"34"},{"groupId":"OG001","value":"34"}],"units":"Participants"}],"description":"SUVmax is categorized as high (\\>median) and low (\\</=median). All times are measured from randomization. Overall survival is defined as time from randomization to date of death from any cause. PFS is time to loco-regional failure (LRP), distant disease progression (DDP), or death. LRF is time to LRP, DDP, or death, with DDP considered a competing risk. Patients last known to be alive without event are censored at the date of last contact. LRP is defined as an estimated increase in the size of the tumor (product of the perpendicular diameters of the two largest dimensions) of greater than 25%, taking as reference the smallest value of all previous measurements or appearance of new areas of malignant disease. DDP is defined as clear evidence of distant metastases. Three-year LRF rates were estimated by the cumulative incidence method. Three-year PFS and OS rates were estimated by the Kaplan-Meier method.","dispersionType":"95% Confidence Interval","groups":[{"description":"Less than or equal to median pretreatment PET SUVmax","id":"OG000","title":"Low PET SUVmax"},{"description":"Greater than median pretreatment PET SUVmax","id":"OG001","title":"High PET SUVmax"}],"paramType":"NUMBER","populationDescription":"Randomized eligible N2-3 patients with follow-up and PET data","reportingStatus":"POSTED","timeFrame":"From randomization until 434 failures have occurred, approximately 5 years from start of study. (Patients are followed until death or study termination, whichever occurs first.)","title":"Correlation of Pre-treatment Positron Emission Tomography (PET)/CT Maximum Standardized Uptake Value (SUVmax) With PFS, OS, and LRF","type":"SECONDARY","unitOfMeasure":"percentage of participants"}