{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.39","value":"22.91"},{"groupId":"OG001","spread":"1.73","value":"22.46"},{"groupId":"OG002","spread":"5.03","value":"22.24"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"8"}],"units":"Participants"}],"description":"Plasma decay half-life is the time measured for the plasma concentration to decrease by one half.\n\nNA = not estimable.","dispersionType":"Standard Deviation","groups":[{"description":"Single oral dose of bosutinib 400 mg on Day 1 and then bosutinib 400 mg orally once daily continuously from Day 3 up to Week 4. All participants who completed treatment in Part 1 were continued in CP2L-CML Part 2 of the study.","id":"OG000","title":"Bosutinib 400 mg (Part 1)"},{"description":"Single oral dose of bosutinib 500 mg on Day 1 and then bosutinib 500 mg orally once daily continuously from Day 3 up to Week 4. All participants who completed treatment in Part 1 were continued in CP2L-CML Part 2 of the study.","id":"OG001","title":"Bosutinib 500 mg (Part 1)"},{"description":"Single oral dose of bosutinib 600 mg on Day 1 and then bosutinib 600 mg orally once daily continuously from Day 3 up to Week 4. All participants who completed treatment in Part 1 were continued in CP2L-CML Part 2 of the study. Eleven participants who completed treatment in Part 1 were continued in CP2L-CML Part 2 of the study and 1 participant was continued in AP-CML Part 2 of the study.","id":"OG002","title":"Bosutinib 600 mg (Part 1)"}],"paramType":"MEAN","populationDescription":"Evaluable population included all enrolled participants who received at least 1 dose of study medication and had an adequate baseline efficacy assessment. 'N' (number of participants analyzed) signifies number of participants who were evaluable for this measure.","reportingStatus":"POSTED","timeFrame":"0 (pre-dose), 1, 2, 3, 4, 6, 8, 24, 48 hours post-dose on Day 1","title":"Plasma Decay Half-Life (t1/2) - Part 1","type":"PRIMARY","unitOfMeasure":"hrs"}