{"eventGroups":[{"description":"A cycle of therapy consisted of bortezomib 1.3 mg/m(2) intravenously; dexamethasone 40 mg on days 1, 4, 8, and 11; and rituximab 375 mg/m(2) on day 11. Patients received four consecutive cycles for induction therapy and then four more cycles, each given 3 months apart, for maintenance therapy.","id":"EG000","otherNumAffected":23,"otherNumAtRisk":23,"seriousNumAffected":19,"seriousNumAtRisk":23,"title":"Bortezomib, Dexamethasone, Rituximab"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"9 patients, grade 2","organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":23,"numEvents":9}],"term":"Peripheral Neuropathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"10 patients, grade 2","organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":23,"numEvents":10}],"term":"Infection without Neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"18 patients, grade 2","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":23,"numEvents":18}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"8 patients, grade 2","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":23,"numEvents":8}],"term":"Thrombocytopenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"6 patients, grade 2","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":23,"numEvents":6}],"term":"neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"6 patients, grade 2","organSystem":"Endocrine disorders","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":23,"numEvents":6}],"term":"hyeprglycemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"5 patients, grade 2.","organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":23,"numEvents":5}],"term":"herpes zoster"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"2 patients, grade 2","organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":23,"numEvents":2}],"term":"Pneumonia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"4 patients, grade 2","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":23,"numEvents":4}],"term":"Fatigue"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"3 patients, grade 2","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":23,"numEvents":3}],"term":"Insomnia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"3 patients, grade 2","organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":23,"numEvents":3}],"term":"dyspnea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"3 patients, grade 2","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":23,"numEvents":3}],"term":"dehydration"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"3 patients, grade 2","organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":23,"numEvents":3}],"term":"cough"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"2 patients, grade 2","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":23,"numEvents":2}],"term":"arrythmia"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"7 patients, grade 3","organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":7,"numAtRisk":23,"numEvents":7}],"term":"Peripheral Neuropathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"6 patients, grade 3","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":23,"numEvents":6}],"term":"Neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"2 patients, grade 3","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":23,"numEvents":2}],"term":"thrombocytopenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"1 patient, grade 3","organSystem":"Musculoskeletal and connective tissue disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":23,"numEvents":1}],"term":"myopathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"1 patient, grade 3","organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":23,"numEvents":1}],"term":"Pneumonia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"1 patient, grade 3","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":23,"numEvents":1}],"term":"Infection with Neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"1 patient, grade 3","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":23,"numEvents":1}],"term":"hypotension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"1 patient, grade 3","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":23,"numEvents":1}],"term":"arrythmia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"1 patient, grade 3","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":23,"numEvents":1}],"term":"anemia"}]}