{"groups":[{"description":"Auto-HCT mobilization is cyclophosphamide 4 g/m2 + filgrastim 10 µg/kg/day for peripheral blood progenitor cell (PBPC) collection by apheresis. Transplant conditioning is high-dose melphalan 200 mg/m2, followed by PBPC infusion as melphalan rescue \\[ie, autologous hematopoietic cells transplant (Auto-HCT)\\]. Post-infusion support is filgrastim 5 µg/kg/day, starting 6 days after melphalan. Stable/responsive disease at 4 weeks continues to allogenic HCT (Allo-HCT) from sibling donor fully-matched for human leukocyte antigen (HLA). Allo-HCT conditioning is total body irradiation (TBI) 200 centigray (cGy) + cyclosporine (CSP) 6.25 mg/kg + mycophenolate mofetil (MMF) 15 mg/kg. Donor mobilization is filgrastim 16 µg/kg/day on day -4 to Day 0; apheresis collections on Day -1 \\& Day 0, to a target of \\> 5 x 10e6 CD34 cells/kg. Allo-HCT is infused to participant on Day 0, with premedication hydrocortisone 100 mg IV \\& diphenhydramine 50 mg IV. CSP tapering on Day 56 to Day 180, adjusted as needed.","id":"FG000","title":"Auto- Then Allo-HCT"}],"periods":[{"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"63"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"63"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"}],"type":"NOT COMPLETED"}],"title":"Autologous HCT (Auto-HCT)"},{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"1"}],"type":"Physician Decision"},{"reasons":[{"groupId":"FG000","numSubjects":"2"}],"type":"Relapse"},{"reasons":[{"groupId":"FG000","numSubjects":"1"}],"type":"Lack of allogenic donor"}],"milestones":[{"achievements":[{"comment":"Not all participants who received autologous transplant continued to receive allogeneic transplant.","groupId":"FG000","numSubjects":"63"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"59"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"4"}],"type":"NOT COMPLETED"}],"title":"Inter-treatment Period"},{"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"59"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"59"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"}],"type":"NOT COMPLETED"}],"title":"Allogenic HCT (Allo-HCT)"}]}