{"eventGroups":[{"description":"The Bexxar therapeutic regimen is delivered in two sets of intravenous infusions given 7-14 days apart. Nonradioactive Tositumomab is given before both the \"dosimetric\" infusion and the \"therapeutic\" infusion to improve distribution of these doses throughout the body. A trace amount of radioactive Iodine 131 Tositumomab is initially given to enable physicians to evaluate the clearance of radiation from the subject's body with gamma camera scans. Calculations made on the basis of these individualized radiation clearance rates allow the therapeutic dose (given 7-14 days after the dosimetric infusion) to be tailored for each patient. The therapeutic dose contains Tositumomab labeled with the amount of Iodine 131 tositumomab specifically calculated based on the scans performed following the dosimetric dose.","id":"EG000","otherNumAffected":15,"otherNumAtRisk":16,"seriousNumAffected":3,"seriousNumAtRisk":16,"title":"Bexxar Therapeutic"}],"frequencyThreshold":"5","otherEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":16,"numEvents":3}],"term":"Hemoglobin"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":7,"numAtRisk":16,"numEvents":7}],"term":"Leukocytes (total WBC)"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":16,"numEvents":5}],"term":"Lymphopenia"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":16,"numEvents":10}],"term":"Neutrophils/granulocytes (ANC/AGC)"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":16,"numEvents":12}],"term":"Platelets"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":16,"numEvents":3}],"term":"Fatigue (asthenia, lethargy, malaise)"},{"organSystem":"Skin and subcutaneous tissue disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":16,"numEvents":4}],"term":"Rash/desquamation"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":16,"numEvents":3}],"term":"Diarrhea"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":16,"numEvents":1}],"term":"Flatulence"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":16,"numEvents":2}],"term":"Nausea"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":16,"numEvents":2}],"term":"Infection with normal ANC or Grade 1 or 2 neutrophils"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":16,"numEvents":2}],"term":"Phosphate, serum-low (hypophosphatemia)"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":16,"numEvents":2}],"term":"Pain - Other"},{"organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":16,"numEvents":3}],"term":"Cough"}],"seriousEvents":[{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":16,"numEvents":1}],"term":"Infection with Normal Neutrophil Count"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":16,"numEvents":1}],"term":"Infection wtih Unknown Neutrophil Count"},{"organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":16,"numEvents":1}],"term":"Neuropathy - Motor"}]}