{"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"description":"The outcome of immune reconstitution was not analyzed by the collaborating laboratory because only a small number of patients were only enrolled in Dose Level 1 (no alemtuzumab). The Dose Level 1 patients were going to be the baseline for which to compare the other patients on Dose Level 2 (and 3) who would have received alemtuzumab. The collaborating investigator determined that the study was not worthwhile performing based on this information.","groups":[{"description":"Patients receive fludarabine phosphate IV over 30 minutes on days -4, -3, and -2. Patients also undergo low-dose TBI on day 0.\n\nTotal-body irradiation: Undergo low-dose total-body irradiation\n\nFludarabine phosphate: Given IV\n\nAllogeneic hematopoietic stem cell transplantation: Undergo allogeneic stem cell transplantation\n\nPeripheral blood stem cell transplantation: Undergo peripheral blood stem cell transplantation","id":"OG000","title":"Dose Level 1 (No Campath)"},{"description":"Patients receive alemtuzumab IV over 6 hours once daily on days -5 and -4 and fludarabine phosphate IV over 30 minutes on days -4, -3, and -2. Patients also undergo low-dose TBI on day 0.\n\nAlemtuzumab: Given IV\n\nTotal-body irradiation: Undergo low-dose total-body irradiation\n\nFludarabine phosphate: Given IV\n\nAllogeneic hematopoietic stem cell transplantation: Undergo allogeneic stem cell transplantation\n\nPeripheral blood stem cell transplantation: Undergo peripheral blood stem cell transplantation","id":"OG001","title":"Dose Level 2 (40mg Total Dose Campath)"},{"description":"Patients receive alemtuzumab IV over 6 hours once daily on days -6, -5, and -4 and fludarabine phosphate IV over 30 minutes on days -4, -3, and -2. Patients also undergo low-dose TBI on day 0.\n\nAlemtuzumab: Given IV\n\nTotal-body irradiation: Undergo low-dose total-body irradiation\n\nFludarabine phosphate: Given IV\n\nAllogeneic hematopoietic stem cell transplantation: Undergo allogeneic stem cell transplantation\n\nPeripheral blood stem cell transplantation: Undergo peripheral blood stem cell transplantation","id":"OG002","title":"Dose Level 3 (60mg Total Dose Campath)"}],"reportingStatus":"POSTED","timeFrame":"Up to 1 year post-transplant","title":"Immune Reconstitution","type":"SECONDARY"}