{"groups":[{"description":"Patients receive induction chemotherapy comprising docetaxel, cisplatin, and fluorouracil. Treatment repeats every 21 days for 3 courses. Patients achieving a pathologic complete response at the primary site and a clinical complete response in the neck then receive carboplatin once weekly and undergo concurrent radiotherapy once daily, 5 days a week, for 7 weeks. Patients with a partial response at the primary site (i.e., positive biopsy), stable disease, or radiographic evidence of persistent disease in the neck receive docetaxel once weekly for 4 weeks and undergo concurrent radiotherapy once or twice daily, 5 days a week, for 6 weeks.\n\ncisplatin : Given IV\n\nradiation therapy : Patients undergo radiation therapy once or twice daily, 5 days a week, for up to 7 weeks\n\ncarboplatin : Given IV\n\nfluorouracil : Given IV\n\ndocetaxel : Given IV","id":"FG000","title":"Arm I"},{"description":"Patients receive cisplatin IV on weeks 1 and 4 and undergo concurrent radiotherapy once or twice daily, 5 days a week, for 6 weeks.\n\ncisplatin : Given IV\n\nradiation therapy : Patients undergo radiation therapy once or twice daily, 5 days a week, for up to 7 weeks","id":"FG001","title":"Arm II"}],"periods":[{"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"70"},{"groupId":"FG001","numSubjects":"75"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"56"},{"groupId":"FG001","numSubjects":"66"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"14"},{"groupId":"FG001","numSubjects":"9"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}],"preAssignmentDetails":"Patients were randomly assigned in a 1:1 ratio to recieve either induction chemotherapy with 3 cycles of TPF followed by concurrent chemoradiotherapy with either docetaxel or carboplatin or concurrent chemoradiotherapy alone with 2 cycles of bolus cisplatin.","recruitmentDetails":"Between August 24, 2004 and December 29, 2008 145 patients were enrolled across 16 sites."}