{"description":"Patients found not to meet the eligibility requirements are by group policy not followed for adverse events or outcome.","eventGroups":[{"description":"Patients receive VAC chemotherapy comprising vincristine sulfate IV over 1 minute on day 1 of weeks 1-9 and dactinomycin IV over 1 minute and cyclophosphamide IV over 1 hour on day 1 of weeks 1, 4, 7, and 10; VA chemotherapy comprising vincristine sulfate IV over 1 minute on day 1 of weeks 13-21 and dactinomycin IV over 1 minute on day 1 of weeks 13, 16, 19, and 22 (dactinomycin is omitted during radiation therapy); and radiation therapy, 5 days a week, beginning on week 13 and continuing for 4-7 weeks, depending on prescribed dose. Some patients do not receive radiation therapy; some start it at week 24. (closed to accrual as of 08/13/2010)\n\ndactinomycin: Given IV\n\ncyclophosphamide: Given IV\n\nvincristine sulfate: Given IV\n\nradiation therapy: Undergo radiotherapy","id":"EG000","otherNumAffected":74,"otherNumAtRisk":272,"seriousNumAffected":1,"seriousNumAtRisk":272,"title":"Regimen I (Chemotherapy, Radiotherapy)"},{"description":"Patients receive VAC chemotherapy and radiation therapy as in regimen I and VA chemotherapy comprising vincristine sulfate IV over 1 minute on day 1 of weeks 13-21, 25-33, and 37-45 and dactinomycin IV over 1 minute on day 1 of weeks 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, and 46 (dactinomycin is omitted during radiation therapy). Some patients do not receive radiation therapy; some start it at week 13 and some at week 24. Some patients have conventional surgery (second-look) at Week 13 (closed to accrual as of 9/23/2011).\n\nconventional surgery: Some patients may undergo second-look surgery\n\ndactinomycin: Given IV\n\ncyclophosphamide: Given IV\n\nvincristine sulfate: Given IV\n\nradiation therapy: Undergo radiotherapy","id":"EG001","otherNumAffected":27,"otherNumAtRisk":70,"seriousNumAffected":1,"seriousNumAtRisk":70,"title":"Regimen II (Chemotherapy, Radiotherapy, Surgery)"}],"frequencyThreshold":"0","otherEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":14,"numAtRisk":272,"numEvents":14},{"groupId":"EG001","numAffected":9,"numAtRisk":70,"numEvents":9}],"term":"Anemia"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":272,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":70}],"term":"Disseminated intravascular coagulation"},{"organSystem":"Blood and lymphatic system 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