{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"11.11"},{"groupId":"OG002","value":"7.50"},{"groupId":"OG003","value":"9.09"},{"groupId":"OG004","value":"11.90"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"27"},{"groupId":"OG002","value":"40"},{"groupId":"OG003","value":"44"},{"groupId":"OG004","value":"42"}],"units":"Participants"}],"description":"Participants are susceptible to opportunistic infections such as bacterial, fungal, viral, protozoan infections and more due to immune suppression from chemotherapy drugs used to treat their disease.","groups":[{"description":"Patients receive low intensity fludarabine phosphate intravenous (IV) and cyclophosphamide IV on days -6 to -3. Patients undergo donor lymphocyte infusion (DLI) with sirolimus generated donor T-helper 2 (Th2) cells on day 14 (single T-Rapa cell DLI in patients with cluster of differentiation 4 (CD4) count between 100 and 200 inclusive).","id":"OG000","title":"Arm IVD Cohort 1 (Th2 DLI)"},{"description":"Patients with nonlymphoma diagnosis or rapidly progressive lymphoma undergo DLI with multiple infusions of sirolimus generated donor Th2 cells beginning on day 14 (multiple T-Rapa cell DLI in patients with CD4 count lower than 100 or ALC lower than 300).","id":"OG001","title":"Arm IVD Cohort 3 (Multiple Th2 DLI)"},{"description":"Patients receive low-intensity preparative chemotherapy with fludarabine phosphate IV and cyclophosphamide IV on days -6 to -3, cyclosporine by mouth twice a day (PO BID) on days -4 to 100, and standard dose sirolimus PO on days -2 to 14. Patients undergo mobilized allogeneic peripheral blood stem cells (PBSC) on day 0. Patients undergo DLI with 12-day expanded sirolimus-generated donor Th2 cells on day 14.","id":"OG002","title":"Arm IVA (12-day Expanded Th2 DLI)"},{"description":"Arm IVB Patients receive low-intensity preparative chemotherapy with fludarabine phosphate IV and cyclophosphamide IV on days -6 to -3, cyclosporine PO BID on days -4 to 100, and standard dose sirolimus PO on days -2 to 14. Patients undergo mobilized allogeneic PBSC or bone marrow transplant on day 0. Patients undergo DLI with 6-day expanded sirolimus-generated donor Th2 cells on day 14.","id":"OG003","title":"Arm IVB (6-day Expanded Th2 DLI)"},{"description":"Patients receive low-intensity preparative chemotherapy with fludarabine phosphate IV and cyclophosphamide IV on days -6 to -3, cyclosporine PO BID on days -7 to 100 and high dose sirolimus PO on days -4 to 7, Patients undergo mobilized allogeneic PBSC on day 0. Patients undergo DLI with 6-day expanded sirolimus-generated donor Th2 cells on day 14.","id":"OG004","title":"Arm IVC (6-day Expanded Th2 DLI and High Dose Sirolimus)"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"First 100 days post-transplant","title":"Percentage of Patients With Opportunistic Infection","type":"SECONDARY","unitOfMeasure":"percentage of participants"}