{"description":"Unanticipated Problems (UP) and Adverse Events (AE) were reported to IRB according to OHSU's (coordinating center) policies, procedures and guidelines posted on the OHSU IRB web site. NCI Common Toxicity Criteria used to assess AEs.","eventGroups":[{"deathsNumAffected":0,"deathsNumAtRisk":17,"description":"Rituximab: (i.v.) 375 mg/m\\^2 given the evening before blood brain barrier disruption(BBBD) procedure day 1 Carboplatin: (i.a.) 200 mg/m\\^2 /day x 2 days = 400 mg/m\\^2","id":"EG000","otherNumAffected":1,"otherNumAtRisk":17,"seriousNumAffected":16,"seriousNumAtRisk":17,"title":"Rituximab and Carboplatin"}],"frequencyThreshold":"5","otherEvents":[{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Leg Pain"}],"seriousEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":17}],"term":"Neutropenic Fever"},{"notes":"Hospitalized for unresponsiveness","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Unresponsiveness"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Anemia"},{"organSystem":"Musculoskeletal and connective tissue disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Superficial Epidermolysis"},{"organSystem":"Psychiatric disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Neurological Symptoms"},{"organSystem":"Vascular disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Stroke"},{"organSystem":"Vascular disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Chemical Meningitis and Seizures"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":17}],"term":"Extended Hospitalization"},{"organSystem":"Injury, poisoning and procedural complications","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Hospitalized for Fall"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Death"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Carotid Artery Tear"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Electrolyte Imbalance and Increased Blood Sodium"},{"organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Bronchitis"},{"organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":17}],"term":"Atrial Fibrillation"}],"timeFrame":"During study treatment (1 year)."}