{"analyses":[{"ciLowerLimit":"0.614","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.979","estimateComment":"sipuleucel-T/placebo","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.032","paramType":"Hazard Ratio (HR)","paramValue":"0.775","statisticalComment":"Cox regression model with treatment, PSA (ln), and LDH (ln) as the independent variables, stratified by randomization strata.","statisticalMethod":"Regression, Cox","testedNonInferiority":false},{"ciLowerLimit":"0.608","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.965","estimateComment":"Cox regression model with treatment as the independent variable, stratified by randomization strata (sipuleucel-T/placebo)","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":"0.023","paramType":"Hazard Ratio (HR)","paramValue":"0.766","statisticalComment":"Stratified by randomization strata.","statisticalMethod":"Log Rank","testedNonInferiority":false}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"17.7","upperLimit":"23.8","value":"21.7"},{"groupId":"OG001","lowerLimit":"22.8","upperLimit":"27.7","value":"25.8"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"171"},{"groupId":"OG001","value":"341"}],"units":"Participants"}],"description":"Time from randomization until death due to any cause.","dispersionType":"95% Confidence Interval","groups":[{"description":"All subjects randomized to receive placebo. Approximately one-third of the quiescent APCs prepared from a single leukapheresis procedure. Three complete doses were given at approximately 2 week intervals.","id":"OG000","title":"APC-Placebo"},{"description":"All subjects randomized to receive sipuleucel-T. Autologous peripheral blood mononuclear cells, including antigen presenting cells, that have been activated in vitro with a recombinant fusion protein, PAP-GM-CSF. Treatment consists of 3 doses administered approximately 2 weeks apart.","id":"OG001","title":"Sipuleucel-T"}],"paramType":"MEDIAN","reportingStatus":"POSTED","timeFrame":"Event-driven timeframe. Final analysis at 331 events.","title":"Overall Survival","type":"PRIMARY","unitOfMeasure":"Months"}