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Treatment repeats every 21 days for up to 15 courses in the absence of disease progression or unacceptable toxicity.","id":"EG000","otherNumAffected":47,"otherNumAtRisk":64,"seriousNumAffected":2,"seriousNumAtRisk":64,"title":"Standard (APO) With Vincristine (Arm I)"},{"description":"In courses 1-3, patients receive doxorubicin hydrochloride (30 mg/m2) IV, methotrexate (age adjusted dosing) IT, prednisone (120 mg/m2/day), and mercaptopurine (225 mg/m2) as in arm I and vinblastine sulfate (4 mg/m2) IV over 1 minute on days 1, 8, and 15. In courses 4 and 5, patients receive doxorubicin hydrochloride (30 mg/m2) IV, prednisone (120 mg/m2/day), and mercaptopurine (225 mg/m2) as in arm I and vinblastine sulfate (4 mg/m2) as in arm II (courses 1-3). In courses 6-15, patients receive prednisone (120 mg/m2/day) and mercaptopurine (225 mg/m2) as in arm I, vinblastine sulfate (4 mg/m2) IV as in arm II (courses 1-3), and methotrexate (60 mg/m2) IV on day 1. Treatment repeats every 21 days for up to 15 courses in the absence of disease progression or unacceptable toxicity.","id":"EG001","otherNumAffected":52,"otherNumAtRisk":61,"seriousNumAffected":4,"seriousNumAtRisk":61,"title":"Consolidation (Includes Vinblastine) (Arm II)"}],"frequencyThreshold":"0","otherEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":14,"numAtRisk":64,"numEvents":14},{"groupId":"EG001","numAffected":24,"numAtRisk":61,"numEvents":24}],"term":"Anemia"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":64,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":61,"numEvents":1}],"term":"Disseminated intravascular coagulation"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":7,"numAtRisk":64,"numEvents":7},{"groupId":"EG001","numAffected":18,"numAtRisk":61,"numEvents":18}],"term":"Febrile 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