{"description":"104 patients enrolled, 2 are ineligible and not included in adverse event reporting. Therefore, adverse events participants reported is 102.","eventGroups":[{"description":"Patients will receive 6 cycles of Induction chemotherapy consisting of carboplatin and etoposide (Cycles 1, 3, and 5) alternating with ifosfamide and etoposide (Cycles 2, 4, and 6). The entire length of Induction is 18 weeks unless delay occurs due to myelosuppression or unanticipated toxicity. Each cycle of Induction will begin when ANC \\> 750/L and platelets \\> 75,000/L and when off filgrastim (G-CSF) for at least 48 hours. Following the Induction phase (weeks 0-18) those patient in CR will undergo radiation therapy.\n\ncarboplatin: Given IV\n\netoposide: Given IV\n\nifosfamide: Given IV\n\nradiation therapy: craniospinal irradiation","id":"EG000","otherNumAffected":70,"otherNumAtRisk":102,"seriousNumAffected":8,"seriousNumAtRisk":102,"title":"Radiation Therapy (CR From Induction)"}],"frequencyThreshold":"5","otherEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":51,"numAtRisk":102,"numEvents":108}],"term":"Anemia"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":102,"numEvents":9}],"term":"Febrile neutropenia"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":102,"numEvents":16}],"term":"Nausea"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":15,"numAtRisk":102,"numEvents":28}],"term":"Vomiting"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":102,"numEvents":10}],"term":"Infections and infestations - Other, specify"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":23,"numAtRisk":102,"numEvents":39}],"term":"Alanine aminotransferase increased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":15,"numAtRisk":102,"numEvents":22}],"term":"Aspartate aminotransferase increased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":19,"numAtRisk":102,"numEvents":42}],"term":"Lymphocyte count decreased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":53,"numAtRisk":102,"numEvents":104}],"term":"Neutrophil count decreased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":53,"numAtRisk":102,"numEvents":96}],"term":"Platelet count decreased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":48,"numAtRisk":102,"numEvents":114}],"term":"White blood cell decreased"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":102,"numEvents":37}],"term":"Hyperglycemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":102,"numEvents":8}],"term":"Hyperkalemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":102,"numEvents":11}],"term":"Hypermagnesemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":20,"numAtRisk":102,"numEvents":32}],"term":"Hypernatremia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":102,"numEvents":7}],"term":"Hypoalbuminemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":15,"numAtRisk":102,"numEvents":22}],"term":"Hypocalcemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":26,"numAtRisk":102,"numEvents":39}],"term":"Hypokalemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":102,"numEvents":13}],"term":"Hypomagnesemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":31,"numAtRisk":102,"numEvents":57}],"term":"Hyponatremia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":102,"numEvents":12}],"term":"Hypophosphatemia"},{"organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":102,"numEvents":8}],"term":"Headache"}],"seriousEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":1}],"term":"Febrile neutropenia"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":1}],"term":"Nausea"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":2}],"term":"Lymphocyte count decreased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":102,"numEvents":5}],"term":"Neutrophil count decreased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":1}],"term":"Platelet count decreased"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":2}],"term":"White blood cell decreased"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":1}],"term":"Hyperkalemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":3}],"term":"Hypernatremia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":102,"numEvents":3}],"term":"Hypokalemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":1}],"term":"Hypophosphatemia"},{"organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":1}],"term":"Headache"},{"organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":102,"numEvents":1}],"term":"Seizure"}]}