{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.62","upperLimit":"5.50","value":"2.74"},{"groupId":"OG001","lowerLimit":"0.19","upperLimit":"21.08","value":"1.78"}]}],"title":"4 hours"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.053","upperLimit":"3.4","value":"1.5"},{"groupId":"OG001","lowerLimit":"0.15","upperLimit":"7.55","value":"1.53"}]}],"title":"24 hours"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.53","upperLimit":"0.56","value":"0.545"},{"groupId":"OG001","lowerLimit":"0.15","upperLimit":"19.42","value":"1.205"}]}],"title":"48 hours"}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"35"}],"units":"Participants"}],"description":"Total ribonucleic acid (RNA) was isolated from peripheral blood mononuclear cells or patient tissue biopsies and analyzed by quantitative polymerase chain reaction (qPCR). Expression of MDR-1/ABCB1 was determined by qPCR relative to an RNA standard, then normalized to ribosomal RNA (rRNA). Fold change is calculated by dividing the level of MDR-1 in a treated sample (at 4, 24, and 48 hours) measured by qPCR, divided by MDR-1 in the pre-treatment sample. We considered a ≥ 2-fold change a measurable difference, and indicative of successful HDAC inhibition by romidepsin (depsipeptide).","dispersionType":"Full Range","groups":[{"description":"Participants received at least one protocol prescribed dose or higher of Romidepsin intravenously at 14mg/m\\^2 and at 17.5 mg/m\\^2 on days 1, 8, and 15 of a 28 day cycle.","id":"OG000","title":"Peripheral T-cell Lymphoma (PTCL)"},{"description":"Participants received at least one protocol prescribed dose or higher of Romidepsin intravenously at 14mg/m\\^2 and at 17.5 mg/m\\^2 on days 1, 8, and 15 of a 28 day cycle.","id":"OG001","title":"Cutaneous T-cell Lymphoma (CTCL)"}],"paramType":"MEDIAN","populationDescription":"ABCB1 expression of all samples at pretreatment was designated as 1; values at other time points for each patient were calculated relative to the corresponding pretreatment value.","reportingStatus":"POSTED","timeFrame":"4 hours, 24 hours, and 48 hours after Romidepsin","title":"Multidrug Resistance Protein 1 (MDR1) or ATP-binding Cassette Sub-family B Member 1 (ABCB1) Gene Expression","type":"SECONDARY","unitOfMeasure":"Fold change"}