{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.53","upperLimit":"11.03","value":"2.99"},{"groupId":"OG001","lowerLimit":"0.44","upperLimit":"17.30","value":"3.00"}]}],"title":"4 hours"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.67","upperLimit":"6.71","value":"1.97"},{"groupId":"OG001","lowerLimit":"0.037","upperLimit":"17.45","value":"1.78"}]}],"title":"24 hours"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.22","upperLimit":"1.02","value":"0.62"},{"groupId":"OG001","lowerLimit":"0.28","upperLimit":"17.64","value":"1.67"}]}],"title":"48 hours"}],"denoms":[{"counts":[{"groupId":"OG000","value":"18"},{"groupId":"OG001","value":"29"}],"units":"Participants"}],"description":"Fold change is calculated by dividing the level of histone acetylation in a treated sample (at 4, 24, and 48 hours) measured as intensity on a dot blot immunoassay, divided by the intensity in the pre-treatment sample. We considered a ≥ 2-fold change a measurable difference, and indicative of successful HDAC inhibition by romidepsin (depsipeptide).","dispersionType":"Full Range","groups":[{"description":"Participants received at least one protocol prescribed dose or higher of Romidepsin intravenously at 14mg/m\\^2 and at 17.5 mg/m\\^2 on days 1, 8, and 15 of a 28 day cycle.","id":"OG000","title":"Peripheral T-cell Lymphoma (PTCL)"},{"description":"Participants received at least one protocol prescribed dose or higher of Romidepsin intravenously at 14mg/m\\^2 and at 17.5 mg/m\\^2 on days 1, 8, and 15 of a 28 day cycle.","id":"OG001","title":"Cutaneous T-cell Lymphoma (CTCL)"}],"paramType":"MEDIAN","populationDescription":"Global histone acetylation of all samples at pretreatment was designated as 1; values at other time points for each patient were calculated relative to the corresponding pretreatment value.","reportingStatus":"POSTED","timeFrame":"4 hours, 24 hours, and 48 hours after Romidepsin","title":"Fold Change in Histone Acetylation","type":"SECONDARY","unitOfMeasure":"Fold change"}