{"eventGroups":[{"deathsNumAffected":27,"deathsNumAtRisk":36,"description":"Patients receive melphalan IV over 2-3 hours on day -2 and an infusion of IL-2-treated autologous or syngeneic peripheral blood stem cells on day 0. Beginning on day 0, patients also receive IL-2 IV continuously over 5 days followed by 2 days off. Treatment with IL-2 repeats weekly for 4 weeks. Beginning 1 month later, patients undergo maintenance therapy comprising interferon alfa SC 3 times a week in the absence of disease progression or unacceptable toxicity.\n\nmelphalan: Given IV\n\nrecombinant interferon alfa: Given SC\n\naldesleukin: Undergo IL2-treated autologous or syngeneic peripheral blood stem infusion\n\nin vitro-treated peripheral blood stem cell transplantation: Undergo IL2-treated autologous or syngeneic peripheral blood stem infusion","id":"EG000","otherNumAffected":0,"otherNumAtRisk":36,"seriousNumAffected":10,"seriousNumAtRisk":36,"title":"Immunotherapy Treatment"}],"frequencyThreshold":"5","seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":36}],"term":"Delayed ANC Engraftment"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related","organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":36}],"term":"Neutropenic fever"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":36}],"term":"Fever and GI"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related One patient also had diarrhea","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":36}],"term":"Nausea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"one patient transplant related one patient interferon related","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":36}],"term":"cardiac event"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Interferon related","organSystem":"Immune system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":36}],"term":"sarcoidosis/failure to thrive"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related","organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":36}],"term":"hypotension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":36}],"term":"mucositis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":36}],"term":"colitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Transplant related","organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":36}],"term":"fever"}]}