{"analyses":[{"ciLowerLimit":"0.72","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.13","estimateComment":"Hazard ratio (HR) estimation is for Standard Breast Irradiation arm versus Breast Radiation plus regional radiation arm.","groupDescription":"It was estimated that the actuarial five year survival of patients on the control arm of this trial would be 80% and a 5% increase in five year survival with experiment arm is clinically interesting to detect. A sample size of 1832 will ensure 80% power to detect such a difference with two-sided alpha of 0.05.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER_LEGACY","pValue":"0.38","paramType":"Hazard Ratio (HR)","paramValue":"0.91","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"79","upperLimit":"84","value":"82"},{"groupId":"OG001","lowerLimit":"80","upperLimit":"85","value":"83"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"916"},{"groupId":"OG001","value":"916"}],"units":"Participants"}],"description":"Duration of study","dispersionType":"95% Confidence Interval","groups":[{"description":"radiation therapy: Standard Breast Irradiation - A dose of 5000 cGy in 25 fractions at a rate of 200 cGy per day, 5 days a week for 5 weeks will be prescribed to the standard tangent fields.","id":"OG000","title":"Standard Breast Irradiation"},{"description":"regional radiation therapy (to the ipsilateral supraclavicular, axillary and internal mammary nodes)\n\nBreast Radiation plus Regional Radiation - A dose of 5000 cGy in 25 fractions at a rate of 200 cGy per day, 5 days a week for 5 weeks will be prescribed to the modified wide tangent fields.","id":"OG001","title":"Breast Radiation Plus Regional Radiation"}],"paramType":"NUMBER","populationDescription":"Intention-to-treat","reportingStatus":"POSTED","timeFrame":"10 years","title":"Overall Survival","type":"PRIMARY","unitOfMeasure":"percentage of alive at 10 years"}