.cancer-site{--ce-ink:#252523;--ce-muted:#58646c;--ce-blue:#2a6e9e;--ce-line:#dce3e6;--ce-paper:#fff;--ce-wash:#f3f7f9;--sn-gutter:clamp(1.25rem,5vw,5.5rem);background:var(--ce-paper);color:var(--ce-ink);font-family:var(--font-site-sans),Arial,sans-serif;font-size:16px;line-height:1.6}body.cancer-site:before{display:none;content:none}.ce-trial-card>p.ce-harm-summary{font-size:12px;line-height:1.65;background:#f7f5f0;padding:12px;border-radius:3px;color:#5a5549;min-height:0;margin-top:18px}@media (max-width:760px){.cancer-site .ce-curve svg text{font-size:22px}}.cancer-site *{box-sizing:border-box}.cancer-site h1,.cancer-site h2,.cancer-site h3,.cancer-site p{margin:0}.cancer-site h1,.cancer-site h2{font-family:var(--font-site-serif),Georgia,serif;font-weight:400;line-height:1.14;letter-spacing:-.035em}.cancer-site h1{font-size:clamp(36px,4.4vw,62px)}.cancer-site h2{font-size:28px}.cancer-site h3{font-size:17px;line-height:1.4;font-weight:600}.cancer-site a{text-decoration:none;color:inherit}.cancer-site a:hover{color:var(--ce-blue)}.cancer-site button,.cancer-site select{font:inherit}.cancer-site button{cursor:pointer}.cancer-site :focus-visible{outline:3px solid #2378b5;outline-offset:5px}.cancer-site code{overflow-wrap:anywhere;font-size:12px}.cancer-site section{scroll-margin-top:24px}.cancer-site .site-nav{position:sticky;top:0;z-index:40;border-bottom:1px solid #d9d1c6;background:#fff}.cancer-site .wrap{width:min(76rem,calc(100% - 2 * var(--sn-gutter)));margin-inline:auto}.cancer-site .sn-in{display:flex;align-items:center;gap:1.6rem;padding-block:1.1rem}.cancer-site .sn-brand{display:inline-flex;align-items:center;gap:.55rem;font-family:var(--font-site-serif),Georgia,serif;font-size:1.15rem;font-weight:500;letter-spacing:-.01em;color:#252523;text-decoration:none}.cancer-site .sn-brand img{display:block;width:auto;height:24px}.cancer-site .sn-links{display:flex;flex:1;flex-wrap:wrap;gap:1.4rem;font-size:14px;transform:translateY(2px)}.cancer-site .sn-links a{margin-block:-.7rem;padding-block:.7rem;color:#6b6760;font-family:var(--font-site-sans),Arial,Helvetica,sans-serif;font-size:14px;font-weight:500;line-height:1.2;letter-spacing:0;text-transform:none;text-decoration-line:underline;text-decoration-color:transparent;text-decoration-thickness:1px;text-underline-offset:5px;transition:color .16s ease,text-decoration-color .16s ease}.cancer-site .sn-links a.on,.cancer-site .sn-links a:hover{color:#2a6e9e;text-decoration-color:rgba(42,110,158,.32)}.cancer-site .sn-cta{display:inline-flex;align-items:center;justify-content:center;gap:.48rem;min-height:40px;padding:.5rem .85rem;border:1px solid #9cc9e5;border-radius:12px;background:#eaf6ff;color:#184c73;box-shadow:0 3px 0 #b8d9ec,0 7px 14px rgba(24,76,115,.08),inset 0 1px 0 rgba(255,255,255,.72);font-family:var(--font-site-sans),Arial,Helvetica,sans-serif;font-size:14px;font-weight:500;line-height:1.2;text-decoration:none;transition:box-shadow .16s ease,transform .16s ease}.cancer-site .sn-cta:after{content:"\2192";transition:transform .16s ease}.cancer-site .sn-cta:hover{color:#184c73;background:#dff1fd;box-shadow:0 4px 0 #b8d9ec,0 10px 18px rgba(24,76,115,.11),inset 0 1px 0 rgba(255,255,255,.8);transform:translateY(-1px)}.cancer-site .sn-cta:hover:after{transform:translateX(2px)}.cancer-site .sn-cta:active{box-shadow:0 1px 0 #b8d9ec,0 4px 8px rgba(24,76,115,.08);transform:translateY(2px)}.cancer-site .site-nav a:focus-visible{outline:2px solid #2a6e9e;outline-offset:4px}@media (prefers-reduced-motion:reduce){.cancer-site .sn-cta,.cancer-site .sn-cta:after{transition:none}.cancer-site .sn-cta:active,.cancer-site .sn-cta:hover,.cancer-site .sn-cta:hover:after{transform:none}}@media (max-width:900px){.cancer-site .site-nav{top:-56px}.cancer-site .sn-in{flex-wrap:wrap;gap:0 1rem;padding-block:0}.cancer-site .sn-brand{min-height:56px}.cancer-site .sn-cta{align-self:center;min-height:44px;margin-left:auto}.cancer-site .sn-links{order:3;flex-basis:100%;flex-wrap:nowrap;align-items:center;gap:1.6rem;height:45px;margin-inline:calc(-1 * var(--sn-gutter));padding-inline:var(--sn-gutter);overflow-x:auto;border-top:1px solid #d9d1c6;scrollbar-width:none;-webkit-mask-image:linear-gradient(90deg,transparent,#000 5%,#000 95%,transparent);mask-image:linear-gradient(90deg,transparent,#000 5%,#000 95%,transparent)}.cancer-site .sn-links::-webkit-scrollbar{display:none}.cancer-site .sn-links a{display:inline-flex;flex:none;align-items:center;min-height:44px;margin-block:0;padding-block:0}}.ce-skip{position:fixed;top:-90px;left:16px;z-index:100;background:#fff;padding:14px}.ce-skip:focus{top:10px}.cx-subnav{display:flex;flex-wrap:wrap;gap:24px;font-size:14px}.cx-subnav a{color:var(--ce-muted);text-decoration:none;padding-bottom:2px;border-bottom:1px solid transparent}.cx-subnav a:hover{color:var(--ce-blue)}.cx-subnav a[aria-current=page]{color:var(--ce-blue);border-bottom-color:var(--ce-blue)}.cl-page>.cm-prose{margin:34px auto 0}.ce-page{max-width:1360px;margin:0 auto;padding:56px 52px 72px}.ce-eyebrow{font-size:11px;font-weight:600;text-transform:uppercase;letter-spacing:.13em;margin-bottom:16px!important}.ce-eyebrow,.ce-lede{color:var(--ce-muted)}.ce-lede{font-size:20px;max-width:520px;margin-top:24px!important;line-height:1.65}.ce-caption{font-size:12px;color:var(--ce-muted);line-height:1.6;margin-top:14px!important}.ce-text-link{font-size:13px;color:var(--ce-blue)!important;border-bottom:1px solid #c6dbe9;padding-bottom:2px}.ce-button{display:inline-flex;align-items:center;gap:46px;background:var(--ce-blue);color:#fff!important;padding:13px 22px;border-radius:5px;font-size:15px;margin:30px 0 8px;box-shadow:0 2px 3px #19496718}.ce-button:hover{background:#1e547b}.ce-tag{display:inline-block;font-size:10px;letter-spacing:.045em;text-transform:uppercase;background:var(--ce-wash);border:1px solid var(--ce-line);border-radius:3px;padding:3px 7px;color:var(--ce-muted)}.ce-home-hero{display:grid;grid-template-columns:1fr 1fr;gap:80px;align-items:center;padding:25px 0 72px}.ce-home-hero h1{font-size:clamp(38px,4.5vw,65px);line-height:1.12}.ce-home-hero h1 em{font-weight:400;color:var(--ce-blue)}.ce-hero-chart{padding:30px 34px 28px;border:1px solid #d5e1e7;border-radius:9px;background:linear-gradient(135deg,#fff 20%,#f0f7fb);box-shadow:8px 12px 0 #f1f4f5}.ce-hero-chart>h2{font-size:27px;margin-bottom:25px}.ce-hero-chart .ce-chart{background:transparent;border:0;padding:0}.ce-hero-chart .ce-chart h3{font-size:15px}.ce-hero-chart>.ce-text-link{display:inline-block;margin-top:20px}.ce-home-section{border-top:1px solid var(--ce-line);padding-top:32px}.ce-topic-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px;margin-top:25px}.ce-topic-card{display:flex;flex-direction:column;align-items:flex-start;padding:26px 26px 24px;border:1px solid var(--ce-line);border-radius:6px;min-height:232px}.ce-topic-card:hover{background:#f8fbfc;border-color:#88abc3}.ce-topic-card h3{font-family:var(--font-site-serif),Georgia,serif;font-size:26px;font-weight:400;line-height:1.2;letter-spacing:-.02em}.ce-topic-card p{font-size:14px;color:var(--ce-muted);margin:15px 0 24px}.ce-topic-card>.ce-text-link{margin-top:auto}.ce-topic-population{background:var(--ce-wash)}.ce-workspace{max-width:1440px;display:grid;grid-template-columns:260px minmax(0,1fr);margin:auto;min-height:calc(100vh - 91px)}.ce-sidebar{padding:42px 26px 50px 32px;border-right:1px solid var(--ce-line);background:#f8fafb}.ce-sidebar h2{font-size:30px;margin-bottom:9px}.ce-sidebar-group{margin-top:35px}.ce-sidebar-group h3{font-size:12px;color:var(--ce-muted);margin-bottom:12px;font-weight:600}.ce-sidebar-group nav{display:flex;flex-direction:column;gap:7px}.ce-sidebar-group nav a{display:flex;justify-content:space-between;align-items:center;font-size:14px;padding:12px 10px;border:1px solid transparent;border-radius:5px}.ce-sidebar-group nav a[aria-current=page]{background:#e7f2f9;border-color:#c4deef;color:#225f8b}.ce-sidebar-group nav a:hover{background:#edf2f5}.ce-sidebar-group nav a span{font-size:17px}.ce-sidebar-group>p{font-size:14px;color:var(--ce-muted);margin-bottom:12px}.ce-sidebar>.ce-details{margin-top:28px;font-size:13px;border-bottom:0}.ce-sidebar-note{font-size:12px!important;color:var(--ce-muted);margin-top:30px!important;line-height:1.7}.ce-main-panel{padding:40px 36px 56px;min-width:0}.ce-intro h1{font-size:clamp(31px,3.5vw,47px);margin-bottom:15px}.ce-intro>p:last-child{color:var(--ce-muted);font-size:17px;max-width:690px}.ce-tabs{display:flex;gap:28px;border-bottom:1px solid var(--ce-line);margin:28px 0}.ce-tabs button{display:flex;align-items:center;gap:10px;background:none;border:0;border-bottom:3px solid transparent;color:var(--ce-muted);font-size:14px;padding:12px 0}.ce-tabs button[aria-pressed=true]{color:var(--ce-blue);border-color:var(--ce-blue);font-weight:600}.ce-tabs button span{font-size:11px;background:#eaf0f3;border-radius:10px;padding:0 6px}.ce-section-label{display:flex;justify-content:space-between;gap:18px;align-items:center;margin-bottom:20px}.ce-section-label h2{font-size:24px}.ce-section-label>span{font-size:12px;color:var(--ce-muted);max-width:240px}.ce-notice{background:#f3f7f9;border-left:2px solid #86aac3;border-radius:0 3px 3px 0;padding:12px 15px;font-size:12px;line-height:1.7;color:#455b69;margin:16px 0 24px!important}.ce-trial-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:20px;align-items:start}.ce-trial-card{padding:24px 22px 18px;border:1px solid var(--ce-line);border-radius:7px;background:#fff;min-width:0}.ce-card-heading{display:flex;align-items:center;justify-content:space-between;gap:8px;font-size:11px;color:var(--ce-muted);margin-bottom:20px}.ce-trial-card>h2{font-size:30px}.ce-trial-card>h2 a{display:flex;justify-content:space-between}.ce-trial-card>h2 span{font-family:var(--font-site-sans);font-size:22px;color:#5d889f}.ce-trial-card>p{color:var(--ce-muted);font-size:14px;line-height:1.5;min-height:43px;margin-top:11px}.ce-trial-card .ce-chart{border:0;padding:0;background:#fff;margin:25px 0 18px}.ce-chart{background:var(--ce-wash);padding:26px;border-radius:6px;margin:22px 0;scroll-margin-top:25px}.ce-chart figcaption h3{font-size:16px;line-height:1.35;font-weight:600;letter-spacing:-.01em}.ce-chart figcaption p{font-size:11px;color:var(--ce-muted);margin-top:7px}.ce-bars{margin-top:25px}.ce-bar-row{margin:0 0 21px}.ce-bar-label{display:flex;justify-content:space-between;align-items:flex-end;gap:15px;font-size:13px;margin-bottom:8px;line-height:1.3}.ce-bar-label strong{font-size:21px;font-weight:600;font-variant-numeric:tabular-nums}.ce-bar-track{background:#e9eef0;height:24px;position:relative;border-radius:2px;overflow:hidden}.ce-bar-fill{height:100%;background:#2a6e9e;border-radius:2px}.ce-bar-fill.ce-comparator{background:#aabcc5}.ce-ci{top:10px;height:4px;border-radius:1px}.ce-ci,.ce-ci:after,.ce-ci:before{position:absolute;background:#283e4d}.ce-ci:after,.ce-ci:before{content:"";width:2px;height:10px;top:-3px}.ce-ci:before{left:0}.ce-ci:after{right:0}.ce-bar-note{font-size:10px!important;color:var(--ce-muted);margin-top:7px!important;line-height:1.5!important;min-height:0!important}.ce-axis{border-top:1px solid #d9e1e4;padding-top:6px;font-size:10px;color:var(--ce-muted)}.ce-axis,.ce-card-links{display:flex;justify-content:space-between}.ce-card-links{gap:16px;font-size:12px;padding-top:18px;color:var(--ce-blue)}.ce-details{border-top:1px solid var(--ce-line);border-bottom:1px solid var(--ce-line);font-size:14px;margin-top:18px}.ce-details summary{font-size:13px;padding:15px 0;cursor:pointer;font-weight:600}.ce-details[open]{padding-bottom:16px}.ce-details p{margin-bottom:12px}.ce-details a{color:var(--ce-blue);text-decoration:underline;text-underline-offset:3px}.ce-details ul{padding-left:20px;color:var(--ce-muted);font-size:13px;list-style:disc}.ce-details li{margin:12px 0}.ce-bottom-note{margin-top:38px;padding:24px 0 0;border-top:1px solid var(--ce-line);max-width:830px}.ce-bottom-note h2,.ce-bottom-note h3{margin-bottom:10px}.ce-bottom-note p{color:var(--ce-muted);font-size:14px;max-width:730px;margin-bottom:12px}.ce-bottom-note a{color:var(--ce-blue);font-size:14px}.ce-filter-panel{border:1px solid var(--ce-line);border-radius:6px;padding:23px;margin:24px 0}.ce-filter-panel .ce-section-label h2{font-size:23px}.ce-filters{display:grid;grid-template-columns:1fr 1fr;gap:18px}.ce-filters label{font-size:12px;font-weight:600;display:flex;flex-direction:column;gap:7px;color:var(--ce-muted)}.ce-filters select{padding:11px 30px 11px 10px;border:1px solid #c5d0d7;border-radius:4px;background:#fff;color:var(--ce-ink);font-weight:400;font-size:14px;width:100%;text-overflow:ellipsis}.ce-filters select:disabled{opacity:.55}.ce-filter-panel>[role=status]{font-size:13px;margin-top:16px}.ce-filter-panel button{background:none;border:0;text-decoration:underline;color:var(--ce-blue)}.ce-result-heading{display:flex;justify-content:space-between;gap:24px;align-items:start;margin-top:30px}.ce-result-heading h2{font-size:28px}.ce-result-heading p:not(.ce-eyebrow){font-size:13px;color:var(--ce-muted);margin-top:12px}.ce-stat{display:flex;flex-direction:column;text-align:right;min-width:160px}.ce-stat strong{font-family:var(--font-site-serif);font-size:44px;color:var(--ce-blue);line-height:1.1;font-weight:400;letter-spacing:-.04em}.ce-stat span{font-size:11px;color:var(--ce-muted);margin-top:6px}.ce-curve{margin:24px 0}.ce-curve figcaption{display:flex;justify-content:space-between;gap:20px;font-size:14px;font-weight:600;margin-bottom:15px}.ce-curve figcaption span{font-size:11px;font-weight:400;color:var(--ce-muted)}.ce-curve svg{width:100%;height:auto;max-height:390px;overflow:visible}.ce-curve svg text{font:11px var(--font-site-sans);fill:#566772}.ce-population-result>.ce-text-link{display:inline-block;margin-top:20px}.ce-empty{padding:36px;background:#f4f6f7;border-radius:6px;margin:26px 0}.ce-empty h3{margin-bottom:12px}.ce-empty p{font-size:14px;color:var(--ce-muted)}.ce-population-page{max-width:1050px}.ce-population-page>.ce-intro{margin:30px 0}.ce-table-wrap{overflow-x:auto;max-width:100%;margin:16px 0}.cancer-site table{border-collapse:collapse;width:100%;font-size:12px;text-align:left}.cancer-site td,.cancer-site th{padding:10px;border-bottom:1px solid var(--ce-line);min-width:75px;vertical-align:top}.cancer-site caption{font-size:12px;text-align:left;color:var(--ce-muted);margin-bottom:10px}.ce-definition-list{display:grid;grid-template-columns:1fr 1fr;gap:16px;margin:20px 0}.ce-definition-list dt{font-size:12px;color:var(--ce-muted)}.ce-definition-list dd{margin:0;font-size:13px;overflow-wrap:anywhere}.ce-study{max-width:1230px}.ce-study-title{padding-top:34px}.ce-study-title>p:not(.ce-eyebrow){font-family:var(--font-site-serif);font-size:26px;margin:14px 0 20px;line-height:1.4}.ce-study-summary{font-size:20px;line-height:1.6;margin:30px 0!important;max-width:850px}.ce-study-grid{display:grid;grid-template-columns:minmax(0,1.7fr) minmax(0,1fr);gap:62px}.ce-study-grid>section{min-width:0}.ce-study-grid>section>section{margin:32px 0}.ce-study-grid h2{margin-bottom:18px}.ce-study-grid>section>section p{font-size:15px;color:var(--ce-muted);margin-bottom:15px}.ce-study-grid ul{list-style:disc;padding-left:20px;font-size:15px;color:var(--ce-muted)}.ce-study-grid li{margin:14px 0}.ce-reference-panel{border-left:1px solid var(--ce-line);padding-left:30px;padding-top:25px;font-size:13px;min-width:0}.ce-reference-panel h2{font-size:25px}.ce-reference-panel h3{font-size:15px;margin:28px 0 12px}.ce-reference-panel dt{color:var(--ce-muted);font-size:11px;margin-top:18px}.ce-reference-panel dd{margin:3px 0 0}.ce-reference-panel ol{padding-left:17px;list-style:decimal}.ce-reference-panel ol li{margin-bottom:22px}.ce-reference-panel a{color:var(--ce-blue)}.ce-reference-panel li p{font-size:12px;color:var(--ce-muted);margin-top:6px}.ce-reference-panel>.ce-text-link{display:inline-block;margin-top:16px}.ce-reference-panel>.ce-caption{margin-bottom:22px}.ce-prose{max-width:860px}.ce-prose section{margin:36px 0}.ce-prose h2{font-size:29px;margin-bottom:20px}.ce-prose h3{margin:22px 0 12px}.ce-prose p{margin:16px 0;color:var(--ce-muted)}.ce-footer{max-width:1440px;margin:auto;border-top:1px solid var(--ce-line);padding:32px 52px 40px}.ce-footer>p{font-family:var(--font-site-serif);font-size:20px}.ce-footer>div{display:flex;gap:25px;flex-wrap:wrap;margin-top:15px;font-size:11px;color:var(--ce-muted)}.ce-footer>div>span{margin-left:auto}@media (min-width:1600px){.ce-main-panel{padding:48px}.ce-sidebar{padding-top:50px}}@media (max-width:1100px){.ce-home-hero{gap:40px}.ce-page{padding:42px 30px}.ce-workspace{grid-template-columns:225px minmax(0,1fr)}.ce-sidebar{padding:32px 20px}.ce-main-panel{padding:32px 24px}.ce-trial-grid{grid-template-columns:1fr}.ce-trial-card{padding:25px 28px}.ce-section-label{align-items:flex-start}.ce-study-grid{gap:35px}.ce-topic-card{padding:22px}.ce-topic-card h3{font-size:23px}}@media (max-width:760px){.ce-page{padding:32px 20px 48px}.ce-home-hero{grid-template-columns:1fr;gap:32px;padding:10px 0 45px}.ce-home-hero h1{font-size:45px}.ce-lede{font-size:18px;margin-top:20px!important}.ce-hero-chart{padding:24px}.ce-section-label{display:block}.ce-section-label>span{display:block;max-width:none;margin-top:10px}.ce-topic-grid{grid-template-columns:1fr;gap:12px}.ce-topic-card{min-height:190px}.ce-workspace{grid-template-columns:1fr}.ce-sidebar{border-right:0;border-bottom:1px solid var(--ce-line);padding:22px 20px}.ce-sidebar>.ce-details,.ce-sidebar>.ce-eyebrow,.ce-sidebar>.ce-sidebar-note,.ce-sidebar>.ce-text-link,.ce-sidebar>h2{display:none}.ce-sidebar-group{margin-top:0}.ce-sidebar-group nav{flex-direction:row;gap:10px}.ce-sidebar-group nav a{flex:1;gap:14px;padding:10px;font-size:13px;border-color:var(--ce-line);background:#fff}.ce-sidebar-group+.ce-sidebar-group{display:none}.ce-main-panel{padding:28px 20px 45px}.ce-intro h1{font-size:35px}.ce-intro>p:last-child{font-size:15px}.ce-tabs{margin:22px 0}.ce-trial-card{padding:22px 20px}.ce-result-heading{display:block}.ce-stat{text-align:left;margin-top:18px}.ce-stat strong{font-size:40px}.ce-filter-panel{padding:18px}.ce-filters{grid-template-columns:1fr;gap:14px}.ce-curve figcaption{display:block}.ce-curve figcaption span{display:block;margin-top:5px}.ce-definition-list,.ce-study-grid{grid-template-columns:1fr}.ce-study-grid{gap:20px}.ce-study-summary{font-size:18px}.ce-study-title>p:not(.ce-eyebrow){font-size:23px}.ce-reference-panel{border-left:0;border-top:1px solid var(--ce-line);padding-left:0}.ce-chart{padding:20px}.ce-footer{padding:28px 20px}.ce-footer>div{gap:12px 20px}.ce-footer>div>span{margin-left:0;width:100%}.ce-footer>p{font-size:18px}}@media print{.ce-card-links,.ce-filter-panel,.ce-footer,.ce-sidebar,.ce-tabs,.site-nav{display:none}.ce-study-grid,.ce-workspace{display:block}.ce-main-panel,.ce-page{padding:0}.ce-trial-grid{display:block}.ce-trial-card{break-inside:avoid;margin:20px 0}.cancer-site a{text-decoration:underline}.ce-details{border:0}.ce-reference-panel{border:0;padding:0}.ce-bar-fill{print-color-adjust:exact}}.cx-workbench{--cx-blue:#246e9f;--cx-text:#202b35;--cx-muted:#637481;--cx-line:#dce5ea;max-width:1500px;margin:auto;color:var(--cx-text);font-size:16px;background:#fff}.cx-workbench button{font:inherit}.cx-workbench svg{flex-shrink:0}.cx-toolbar{display:flex;align-items:center;justify-content:space-between;padding:17px max(40px,calc((100% - 1120px) / 2));border-bottom:1px solid var(--cx-line)}.cx-toolbar-note{font-size:14px;color:var(--cx-muted)}.cx-mobile-filter{display:none}.cx-layout{display:grid;grid-template-columns:288px minmax(0,1fr)}.cx-controls{padding:28px 24px;background:#f7f9fb;border-right:1px solid var(--cx-line)}.cx-control-heading{display:flex;align-items:center;justify-content:space-between;margin-bottom:26px}.cx-control-heading h2{font:600 18px var(--font-site-sans);letter-spacing:-.02em}.cx-control-heading svg{color:#8095a4}.cx-condition-picker{position:relative;margin-bottom:24px}.cx-condition-picker>label,.cx-field-label,.cx-fieldset legend{display:block;font-size:14px;font-weight:600;margin-bottom:9px}.cx-current-condition{display:flex;align-items:center;justify-content:space-between;width:100%;background:#fff;border:1px solid #b6cbd9;border-radius:6px;padding:12px;text-align:left;gap:12px;font-weight:600!important}.cx-picker-panel{position:absolute;top:83px;left:0;width:340px;z-index:20;border:1px solid var(--cx-line);border-radius:8px;background:#fff;box-shadow:0 16px 55px #29445826;padding:12px}.cx-search{display:flex;align-items:center;gap:9px;border:1px solid #b6cbd9;border-radius:5px;padding:10px 12px}.cx-search input{width:100%;border:0;outline:0;font:inherit;font-size:14px;background:transparent;min-width:0}.cx-picker-panel>p,.cx-search svg{color:var(--cx-muted)}.cx-picker-panel>p{font-size:12px;padding:12px 5px}.cx-picker-panel nav{max-height:310px;overflow:auto}.cx-picker-panel nav>a{display:flex;align-items:center;justify-content:space-between;gap:10px;padding:10px;font-size:14px;border-radius:4px}.cx-picker-panel nav>a:hover,.cx-picker-panel nav>a[aria-current=page]{background:#eaf3f9;color:var(--cx-blue)}.cx-picker-panel nav>p{font-size:14px;padding:12px}.cx-fieldset{border:0;margin:22px 0;padding:0}.cx-fieldset:disabled{opacity:.5}.cx-segmented{display:flex;border:1px solid #cfdae2;border-radius:5px;overflow:hidden;background:#fff}.cx-segmented button{flex:1;background:transparent;border:0;padding:10px 3px;color:var(--cx-muted);font-size:14px}.cx-segmented button+button{border-left:1px solid #dce5ea}.cx-segmented button[aria-pressed=true]{background:#e7f1f8;color:#1e5f8b;font-weight:600}.cx-select{padding:12px 10px;border:1px solid #cfdae2;border-radius:5px;width:100%;background:#fff;font-size:14px!important;color:var(--cx-text)}.cx-stage-options{display:flex;flex-direction:column;gap:7px}.cx-stage-options button{display:flex;align-items:center;gap:10px;background:#fff;border:1px solid #dce5ea;border-radius:5px;padding:11px 10px;text-align:left}.cx-stage-options button>span:nth-child(2){flex:1}.cx-stage-options strong{font-size:14px;font-weight:500;display:block;line-height:1.3}.cx-stage-options small{font-size:12px;display:block;color:var(--cx-muted);margin-top:3px}.cx-stage-options button[aria-pressed=true]{border-color:#78accd;background:#edf6fb}.cx-stage-options button[aria-pressed=true] strong{color:#1f668f;font-weight:600}.cx-stage-options svg{color:#246e9f}.cx-radio-dot{width:13px;height:13px;border:1px solid #acbcc5;border-radius:100%;flex-shrink:0}.cx-stage-options button[aria-pressed=true] .cx-radio-dot{border:4px solid #246e9f;background:#fff}.cx-extra-filters{margin-top:22px}.cx-extra-filters button{font-size:14px;text-decoration:none!important}.cx-extra-filters p{font-size:13px;color:var(--cx-muted);margin-top:12px;line-height:1.7}.cx-extra-filters label{font-size:13px;display:block;margin-bottom:9px}.cx-reset{border:0;background:none;color:#527286;font-size:13px!important;padding:18px 0 10px;text-decoration:underline;text-underline-offset:4px}.cx-load-status{font-size:13px;color:var(--cx-muted)}.cx-load-status button{border:0;background:none;color:var(--cx-blue);text-decoration:underline}.cx-privacy{display:flex;gap:9px;padding-top:22px;border-top:1px solid var(--cx-line);margin-top:16px}.cx-privacy p{font-size:12px;line-height:1.6;color:var(--cx-muted)}.cx-privacy-mark{width:6px;height:6px;background:#8aa9b7;border-radius:50%;margin-top:7px;flex-shrink:0}.cx-results{padding:31px 36px 40px;min-width:0}.cx-results-heading{display:flex;justify-content:space-between;gap:20px;align-items:center}.cx-breadcrumb{font-size:12px;color:var(--cx-muted);margin-bottom:10px}.cx-breadcrumb span{margin:0 9px;color:#b4c3cd}.cx-results-heading h1{font-size:38px;letter-spacing:-.035em;line-height:1.16}.cx-results-heading p{font-size:14px;color:var(--cx-muted);margin-top:9px}.cx-result-actions{display:flex;gap:8px;align-items:center}.cx-result-actions button{display:flex;align-items:center;justify-content:center;gap:7px;border:1px solid var(--cx-line);background:#fff;border-radius:5px;padding:9px;font-size:12px;min-height:36px}.cx-result-actions button:hover{background:#f1f6f9}.cx-view-tabs{display:flex;gap:27px;border-bottom:1px solid var(--cx-line);margin:25px 0}.cx-view-tabs button{display:flex;align-items:center;gap:8px;background:none;border:0;border-bottom:2px solid transparent;padding:12px 0;font-size:14px;color:var(--cx-muted)}.cx-view-tabs button[aria-pressed=true]{color:var(--cx-blue);border-color:var(--cx-blue);font-weight:600}.cx-result-card{border:1px solid #cbdde8;border-radius:8px;padding:25px 28px 0;box-shadow:0 2px 8px #294a5c05}.cx-stat-heading{display:flex;justify-content:space-between;gap:18px;align-items:flex-start}.cx-stat-label{font-size:16px;font-weight:600;color:#3f5566}.cx-stat-number{font-family:var(--font-site-serif);font-size:clamp(46px,4.4vw,64px);font-weight:400;letter-spacing:-.05em;color:#205e8a;line-height:1.12;margin-top:6px}.cx-stat-number>span{font-family:var(--font-site-sans);font-size:13px;letter-spacing:0;color:var(--cx-muted);display:block;margin-top:4px;line-height:1.5}.cx-stat-number.is-unavailable{font-size:30px;line-height:1.3;letter-spacing:-.025em}.cx-interval{font-size:12px;color:var(--cx-muted);margin-top:7px!important}.cx-horizon{text-align:right;margin-top:2px}.cx-horizon label{display:block;font-size:12px;color:var(--cx-muted);margin-bottom:7px}.cx-horizon select{border:1px solid #cbdbe5;background:#f8fbfc;padding:8px 12px;font-size:14px;border-radius:4px;min-width:118px}.cx-current-label{display:flex;align-items:center;gap:8px;font-size:12px;color:#647685;margin-top:18px}.cx-line-key{display:inline-block;width:17px;height:3px;background:#246e9f;vertical-align:middle;flex-shrink:0}.cx-line-key.comparison{background:repeating-linear-gradient(90deg,#9c672c 0 4px,transparent 4px 7px);margin-left:10px}.cx-plot{margin-top:23px}.cx-plot figcaption{display:flex;align-items:center;justify-content:space-between;color:#758794;font-size:12px;margin-bottom:3px}.cx-plot svg{width:100%;height:auto;max-height:280px;display:block;overflow:visible}.cx-plot svg text{font:12px var(--font-site-sans);fill:#667c8b}.cx-gridline{stroke:#dce6ec;stroke-dasharray:3 5}.cx-plot-caption{display:flex;justify-content:space-between;gap:15px;font-size:12px;color:var(--cx-muted);margin-top:0}.cx-plot-caption>span{display:flex;align-items:center;gap:7px}.cx-chart-years{display:grid;grid-template-columns:repeat(4,1fr);margin-top:19px;border:1px solid #dce5ea;border-radius:5px;overflow:hidden}.cx-chart-years button{border:0;border-right:1px solid #dce5ea;background:#fbfcfd;text-align:left;padding:12px 14px;display:flex;justify-content:space-between;align-items:center;gap:6px}.cx-chart-years button:last-child{border-right:0}.cx-chart-years button[aria-pressed=true]{background:#eaf4fb;box-shadow:inset 0 -2px 0 #2b729f}.cx-chart-years span{font-size:12px;color:var(--cx-muted)}.cx-chart-years strong{font-size:18px;font-weight:500;letter-spacing:-.03em}.cx-comparison-row{display:flex;align-items:center;justify-content:space-between;gap:15px;border-top:1px solid var(--cx-line);margin-top:22px;padding:14px 0;font-size:12px;color:var(--cx-muted)}.cx-comparison-row button{display:flex;align-items:center;gap:7px;background:none;border:0;padding:2px 0;color:#246e9f;font-size:13px}.cx-comparison-row>span:first-child{display:flex;gap:8px;align-items:center}.cx-comparison-note{background:#fbf7f0;border-top:1px solid #ebe2d2;padding:12px 15px;font-size:13px!important;line-height:1.6;margin:0 -28px!important;border-radius:0 0 8px 8px;color:#786647}.cx-reading-note{display:flex;gap:11px;margin:20px 0;color:#657a88}.cx-info{flex-shrink:0;display:flex;align-items:center;justify-content:center;font:italic 12px Georgia;width:17px;height:17px;border:1px solid #a1b8c8;border-radius:50%;margin-top:3px}.cx-reading-note p{font-size:13px;line-height:1.7;max-width:830px}.cx-reading-note strong{color:#435c6d;font-weight:600}.cx-next-grid{display:grid;grid-template-columns:1fr 1fr;gap:14px}.cx-next-grid button{display:flex;align-items:center;gap:13px;background:#f6f9fb;border:1px solid var(--cx-line);border-radius:6px;text-align:left;padding:17px 18px;color:#50758b}.cx-next-grid button>span{flex:1}.cx-next-grid strong{font-size:15px;font-weight:600;display:block;color:#324e60}.cx-next-grid small{font-size:12px;display:block;margin-top:2px;color:var(--cx-muted)}.cx-next-grid button:hover{border-color:#8bb3cc;background:#edf5fa}.cx-source-strip{display:flex;justify-content:space-between;gap:15px;font-size:12px;color:#7f919c;margin-top:20px}.cx-source-strip strong{font-weight:500}.cx-source-panel{border:1px solid var(--cx-line);border-radius:8px;padding:28px}.cx-source-panel h2{font-size:30px;margin-bottom:18px}.cx-source-panel p{font-size:15px;color:#5f7482;line-height:1.75;margin:16px 0}.cx-source-panel table{font-size:14px}.cx-source-panel ul{list-style:disc;padding-left:20px;font-size:14px}.cx-source-panel li{margin:12px 0}.cx-source-panel a{color:var(--cx-blue)}.cx-source-link{display:inline-flex;gap:7px;align-items:center;border-bottom:1px solid #bfdae9;font-size:14px;margin:12px 0}.cx-missing{padding:32px 10px;min-height:230px}.cx-missing h2,.cx-missing h3{font-size:22px;margin-bottom:15px}.cx-missing p{font-size:15px;color:var(--cx-muted);max-width:550px;line-height:1.7}.cancer-site .ce-footer{padding:26px 40px}.cancer-site .ce-footer>p{font-size:16px;color:#566c79}.cancer-site .ce-footer>div{font-size:12px}.cx-workbench button:disabled{opacity:.55;cursor:wait}@media (min-width:1500px){.cx-results{padding-left:48px;padding-right:48px}.cx-result-card{padding-left:35px;padding-right:35px}.cx-comparison-note{margin-left:-35px!important;margin-right:-35px!important}}@media (max-width:1100px){.cx-layout{grid-template-columns:255px minmax(0,1fr)}.cx-controls{padding:25px 20px}.cx-results{padding:28px 24px}.cx-results-heading h1{font-size:34px}.cx-result-actions button>span{display:none}.cx-result-card{padding:23px 20px 0}.cx-comparison-note{margin-left:-20px!important;margin-right:-20px!important}.cx-chart-years button{display:block;padding:10px 13px}.cx-chart-years strong{display:block;margin-top:2px}.cx-next-grid{grid-template-columns:1fr}.cx-next-grid button{padding:14px 16px}.cx-source-strip{display:block}.cx-source-strip span{display:block;margin-top:6px}}@media (max-width:760px){.cx-toolbar{padding:12px 20px}.cx-toolbar .cx-subnav,.cx-toolbar-note{display:none}.cx-mobile-filter{display:flex;align-items:center;gap:7px;font-size:13px!important;background:#fff;border:1px solid #bdcfdc;border-radius:5px;padding:8px 10px;color:#246e9f}.cx-layout{display:flex;flex-direction:column}.cx-controls{display:none}.cx-controls.is-open{padding:20px;border-right:0;border-bottom:1px solid var(--cx-line);display:grid;grid-template-columns:1fr 1fr;gap:18px 15px}.cx-control-heading{display:none}.cx-condition-picker{grid-column:1/-1;margin:0}.cx-picker-panel{top:80px;width:100%;max-width:none}.cx-fieldset{margin:0;min-width:0}.cx-controls>.cx-field-label{grid-column:2;grid-row:2;margin:0;align-self:start}.cx-controls>.cx-select{grid-column:2;grid-row:2;margin-top:32px;height:44px}.cx-stage-field{grid-column:1/-1}.cx-stage-options{display:grid;grid-template-columns:repeat(3,1fr);gap:7px}.cx-stage-options button{padding:10px 8px;min-height:65px;gap:0}.cx-stage-options .cx-radio-dot,.cx-stage-options svg{display:none}.cx-stage-options strong{font-size:14px}.cx-stage-options small{font-size:12px;line-height:1.3}.cx-extra-filters{grid-column:1/-1;margin:0}.cx-extra-filters [data-state=closed]{border:0}.cx-extra-filters button{padding:4px 0;font-size:14px}.cx-privacy{grid-column:1/-1;margin:0;padding:0;border:0}.cx-privacy br{display:none}.cx-privacy p{font-size:12px}.cx-reset{padding:0;text-align:left}.cx-load-status,.cx-reset{grid-column:1/-1}.cx-results{padding:22px 16px 32px}.cx-breadcrumb{display:none}.cx-results-heading h1{font-size:33px}.cx-results-heading p{font-size:13px;line-height:1.5;max-width:255px}.cx-result-actions{gap:5px;align-self:flex-start}.cx-result-actions button{padding:7px;min-height:32px}.cx-result-actions button:last-child{display:none}.cx-view-tabs{gap:16px;margin:18px 0;justify-content:space-between}.cx-view-tabs button{font-size:13px;gap:5px;white-space:nowrap}.cx-view-tabs svg{display:none}.cx-result-card{padding:20px 16px 0}.cx-stat-label{font-size:15px}.cx-stat-number{font-size:52px}.cx-stat-number>span{font-size:12px}.cx-horizon label{display:none}.cx-horizon select{font-size:14px;min-width:90px;padding:7px}.cx-interval{max-width:210px}.cx-current-label,.cx-interval{font-size:12px;line-height:1.5}.cx-plot{margin-top:20px}.cx-plot svg text{font-size:32px}.cx-plot figcaption{font-size:12px}.cx-plot-caption{display:none}.cx-chart-years{margin-top:10px}.cx-chart-years button{padding:10px 8px}.cx-chart-years span{font-size:12px}.cx-chart-years strong{font-size:18px}.cx-comparison-row{display:block;margin-top:16px;padding:14px 0}.cx-comparison-row>span:last-child{display:block;margin-top:9px;font-size:12px}.cx-comparison-note{margin-left:-16px!important;margin-right:-16px!important;font-size:12px!important}.cx-reading-note p{font-size:13px}.cx-next-grid button{padding:15px}.cx-source-panel{padding:20px}.cx-source-panel h2{font-size:27px}.cancer-site .ce-footer{padding:25px 20px}.cx-plot .cx-missing{min-height:180px}.cx-missing p{font-size:14px}}.cx-directory h1{font-size:clamp(40px,5vw,66px);letter-spacing:-.04em;margin-top:12px}.cx-directory>.ce-eyebrow{margin-top:35px}.cx-directory .ce-lede{max-width:720px}.cx-directory-note{font-size:14px;line-height:1.7;color:#607583;border-block:1px solid #dce5ea;padding:18px 0;margin:28px 0}.cx-directory-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:0 30px}.cx-directory-grid>a{padding:22px 0;border-bottom:1px solid #dce5ea;min-width:0}.cx-directory-grid strong{font-size:17px;line-height:1.5;color:#246e9f;display:flex;justify-content:space-between;gap:16px;font-weight:500}.cx-directory-grid>a>span{display:block;font-size:12px;color:#637481;line-height:1.6;margin-top:7px}.cx-directory-grid>a:hover strong{text-decoration:underline;text-underline-offset:5px}@media (max-width:950px){.cx-directory-grid{grid-template-columns:repeat(2,minmax(0,1fr))}}@media (max-width:600px){.cx-directory-grid{grid-template-columns:1fr}}.cx-confidence-key{font-size:12px;color:var(--cx-muted);line-height:1.6;margin-top:10px}.cx-source-panel code{overflow-wrap:anywhere;font-size:12px}.cx-source-coordinates{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px 20px;padding:18px 0;border-block:1px solid var(--cx-line);margin-block:20px}.cx-source-coordinates dt{font-size:12px;color:var(--cx-muted)}.cx-source-coordinates dd{font-size:14px;margin-top:4px}.cx-research-heading{display:flex;justify-content:space-between;gap:20px;align-items:flex-start;margin-bottom:22px}.cx-research h2{font-size:28px;line-height:1.25;letter-spacing:-.025em}.cx-registry>p,.cx-research-heading p{font-size:15px;color:var(--cx-muted);line-height:1.7;margin-top:10px}.cx-research-tag{font-size:12px;line-height:1.5;border:1px solid #cbdde8;border-radius:4px;padding:7px 10px;color:#537489;max-width:125px}.cx-research-focus{display:flex;flex-wrap:wrap;gap:8px;align-items:center;margin:20px 0}.cx-research-focus>span{font-size:13px;color:var(--cx-muted);margin-right:4px}.cx-research-focus button{background:#fff;border:1px solid var(--cx-line);border-radius:5px;font-size:13px;padding:9px 12px}.cx-research-focus button[aria-pressed=true]{background:#edf6fb;border-color:#8bb3cc;color:#246e9f}.cx-curated-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px;align-items:start}.cx-curated-card{border:1px solid var(--cx-line);border-radius:8px;padding:22px;min-width:0}.cx-study-eyebrow{display:flex;justify-content:space-between;gap:10px;font-size:12px;color:var(--cx-muted);margin-bottom:14px}.cx-curated-card>h3{font-size:27px;letter-spacing:-.025em}.cx-study-title{font-size:14px;line-height:1.6;color:var(--cx-muted);margin-top:7px;min-height:45px}.cx-curated-card .ce-chart{padding:22px 0 15px;margin:12px 0 0;border:0;border-radius:0;background:#fff;box-shadow:none}.cx-curated-card .ce-chart h3{font-family:var(--font-site-sans);font-size:16px;letter-spacing:0}.cx-curated-card .ce-chart figcaption>p{font-size:12px;line-height:1.5}.cx-curated-card .ce-bar-label{font-size:14px;align-items:flex-end}.cx-curated-card .ce-bar-label strong{font-size:25px}.cx-curated-card .ce-bar-note,.cx-curated-card .ce-caption{font-size:12px;line-height:1.6}.cx-curated-card .ce-bar-track{height:19px}.cx-curated-card .ce-axis{font-size:12px}.cx-curated-card .ce-bars{gap:20px}.cx-severe{background:#f7f4ef;border-radius:4px;padding:12px 14px;color:#756249;line-height:1.6;margin:5px 0 12px}.cx-severe strong{display:block;font-size:14px;font-weight:600}.cx-severe span{font-size:12px;display:block;margin-top:5px}.cx-curated-card [data-slot=accordion-trigger]{font-size:14px}.cx-curated-card [data-slot=accordion-content]{font-size:14px;line-height:1.7;color:var(--cx-muted)}.cx-curated-card li{list-style:disc;margin:10px 0 0 16px}.cx-curated-card [data-slot=accordion-content] p+p{margin-top:12px}.cx-curated-card>a{display:flex;align-items:center;gap:8px;font-size:14px;color:#246e9f;padding-top:20px}.cx-research-footnote{font-size:13px;line-height:1.7;color:var(--cx-muted);margin-top:18px}.cx-curation-gap{display:flex;gap:17px;background:#f4f8fb;border:1px solid var(--cx-line);border-radius:6px;padding:24px;color:#54778e}.cx-curation-gap h3{font-family:var(--font-site-sans);font-size:17px;letter-spacing:-.01em;color:#354f60}.cx-curation-gap p{font-size:14px;line-height:1.7;color:#607b8c;margin-top:9px;max-width:650px}.cx-registry{margin-top:38px;border-top:1px solid var(--cx-line);padding-top:28px}.cx-registry-heading{display:flex;align-items:center;justify-content:space-between;gap:20px}.cx-registry-heading>span{font-size:12px;color:var(--cx-muted);text-align:right}.cx-registry-filters{display:grid;grid-template-columns:minmax(0,1fr) 190px 115px;gap:10px;margin:20px 0}.cx-registry-filters select{width:100%;font-size:13px;background:#fff;border:1px solid #b6cbd9;border-radius:5px;padding:10px;min-width:0;color:#3f5a6d}.cx-registry-filters .cx-search input{font-size:14px}.cx-registry-count{font-size:13px;color:var(--cx-muted);margin-bottom:12px}.cx-registry-list{border:1px solid var(--cx-line);border-radius:7px;overflow:hidden}.cx-registry-list:empty{display:none}.cx-registry-list article{padding:23px 25px}.cx-registry-list article+article{border-top:1px solid var(--cx-line)}.cx-registry-meta{display:flex;gap:10px 18px;flex-wrap:wrap;align-items:center;font-size:12px;color:var(--cx-muted);margin-bottom:12px}.cx-status-recruiting{color:#356e66;background:#eef7f3;padding:4px 8px;border-radius:4px}.cx-registry-list h3{font:500 18px/1.5 var(--font-site-sans);letter-spacing:-.015em;color:#36576d}.cx-registry-list h3 svg{display:inline-block;vertical-align:middle;margin-left:7px}.cx-registry-list article>p{font-size:13px;color:var(--cx-muted);margin:10px 0;line-height:1.6}.cx-registry-bottom{display:flex;flex-wrap:wrap;gap:8px 20px;font-size:12px;color:var(--cx-muted);margin-top:14px}.cx-registry-bottom a{color:#246e9f;margin-left:auto}.cx-more-studies{display:block;margin:20px auto 0;border:1px solid #a9c4d5;padding:10px 20px;background:#fff;border-radius:5px;color:#246e9f;font-size:14px!important}.cx-live-source{display:flex;align-items:center;gap:24px;justify-content:space-between;margin-top:22px}.cx-live-source p{font-size:12px;line-height:1.7;color:var(--cx-muted);max-width:440px}.cx-live-source a{display:flex;align-items:center;gap:7px;color:#246e9f;font-size:13px;line-height:1.6}.cx-registry-status{padding:35px 0;font-size:14px;color:var(--cx-muted)}.cx-registry-status button{border:0;background:none;text-decoration:underline;color:#246e9f}.cx-workbench :is(button,a,select,input):focus-visible{outline:3px solid #75aaca;outline-offset:3px}.cx-search:focus-within{outline:2px solid #75aaca;outline-offset:2px}.cx-curated-card>a:hover,.cx-registry-list a:hover{text-decoration:underline;text-underline-offset:4px}@media (max-width:1100px){.cx-curated-grid{grid-template-columns:1fr}.cx-registry-heading{display:block}.cx-registry-heading>span{display:block;text-align:left;margin-top:8px}.cx-registry-filters{grid-template-columns:1fr 120px}.cx-registry-filters .cx-search{grid-column:1/-1}.cx-live-source{align-items:flex-start;flex-direction:column;gap:10px}}@media (max-width:760px){.cx-research-heading{gap:12px}.cx-research h2{font-size:26px}.cx-research-tag{display:none}.cx-research-heading p{font-size:14px}.cx-curation-gap{padding:20px 16px;gap:12px}.cx-curated-card{padding:19px}.cx-research-focus>span{width:100%}.cx-research-focus button{font-size:12px;padding:9px}.cx-registry-list article{padding:20px 17px}.cx-registry-list h3{font-size:17px}.cx-registry-bottom{gap:9px}.cx-registry-bottom span{width:100%}.cx-registry-bottom a{margin:0}.cx-confidence-key{font-size:12px}.cx-source-coordinates{grid-template-columns:1fr}.cx-stat-number{overflow-wrap:anywhere}.cx-controls.is-open{scroll-margin-top:20px}}@media print{.cx-comparison-row button,.cx-controls,.cx-next-grid,.cx-result-actions,.cx-toolbar,.cx-view-tabs{display:none}.cx-layout{display:block}.cx-results{padding:0}.cx-result-card{break-inside:avoid}.cx-source-strip{display:block}.cx-workbench{max-width:none}.cx-plot svg{print-color-adjust:exact}.cx-curated-grid{display:block}.cx-curated-card{break-inside:avoid;margin-bottom:20px}.cx-more-studies,.cx-registry-filters{display:none}}.cl-page{max-width:1200px;margin:auto;padding:17px 40px 60px;color:#25323c;font-size:1rem}.cl-page a,.cl-treatment-panel a{text-decoration:none}.cl-subnav{display:flex;justify-content:space-between;align-items:center;gap:20px;border-bottom:1px solid #dfe8ee;padding-bottom:17px;font-size:14px;color:#276e9d}.cl-subnav .cx-toolbar-note{font-size:14px;color:var(--ce-muted)}.cl-page-heading{margin:34px 0 26px;max-width:880px}.cl-eyebrow{color:#347aa9;font-size:.8rem;letter-spacing:.13em;font-weight:600;margin-bottom:12px}.cl-page-heading h1{font:500 clamp(1.9rem,3.5vw,2.75rem) /1.15 var(--font-site-serif);letter-spacing:-.025em;margin-bottom:16px}.cl-page-heading>p:last-child{color:#60707d;max-width:760px;line-height:1.65}.cl-heading{display:flex;justify-content:space-between;align-items:start;gap:24px;margin-bottom:20px}.cl-heading h2{font:500 1.7rem/1.25 var(--font-site-serif);margin-bottom:12px}.cl-heading p,.cl-note{line-height:1.6}.cl-note{padding:14px 18px;background:#f1f7fb;border-left:3px solid #a3c8e1;color:#4c6575;font-size:.94rem;margin:20px 0}.cl-topic-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}.cl-topic-card{display:flex;flex-direction:column;align-items:start;padding:22px;border:1px solid #d5e3ed;border-radius:12px;background:linear-gradient(135deg,#fff,#f7fbff);transition:border-color .15s,box-shadow .15s}.cl-topic-card:hover{border-color:#7fb5dc;box-shadow:0 5px 18px #49779812}.cl-topic-card h3{font:500 1.35rem/1.3 var(--font-site-serif);margin:10px 0}.cl-topic-card p{color:#5d6d78;font-size:.94rem;line-height:1.5;margin-bottom:18px}.cl-next a,.cl-text-link{color:#2875a7;font-size:.94rem}.cl-text-link{margin-top:auto}.cl-meta{color:#667883;font-size:.875rem;line-height:1.5}.cl-reader-controls{display:flex;gap:20px;margin:28px 0 16px}.cl-reader-controls label{display:flex;flex-direction:column;gap:8px;font-size:.94rem;flex:1}.cl-reader-controls input,.cl-reader-controls select{padding:12px 14px;border:1px solid #bccedb;border-radius:8px;background:white;font:inherit;color:inherit;min-width:0;width:100%}.cl-reader-controls label:first-child{flex:2}.cl-section-list{margin-top:20px;border-top:1px solid #dce6ed}.cl-section-list>a{display:flex;gap:24px;justify-content:space-between;align-items:center;padding:19px 10px;border-bottom:1px solid #dce6ed}.cl-section-list>a:hover{background:#f4f9fc}.cl-section-list h2{font:600 1.06rem/1.45 var(--font-site-sans);margin-top:5px}.cl-section-list a>span:last-child{color:#367bab}.cl-filter-row{display:flex;gap:8px;margin:20px 0;flex-wrap:wrap}.cl-filter-row button{border:1px solid #c3d6e4;padding:8px 14px;border-radius:8px;font:inherit;font-size:.94rem;background:white}.cl-filter-row button[aria-pressed=true]{background:#e9f4fc;color:#246f9d;border-color:#91bfdf}.cl-next{border-top:1px solid #dfe8ee;margin-top:28px;padding-top:24px}.cl-next h3{font-size:1.1rem;margin-bottom:8px}.cl-next p{color:#637581;margin-bottom:12px;line-height:1.6}.cl-review-note{margin:40px 0 0;padding-top:20px;border-top:1px solid #dfe8ee;font-size:.875rem;color:#637581}.cl-reading{max-width:850px;font-size:1.0625rem;line-height:1.75}.cl-reading .source-block{margin:22px 0}.cl-reading .source-parent-context{font-weight:600}.cl-reading .source-list-item{padding-left:20px;border-left:2px solid #dbe7f0}.cl-reading table{border-collapse:collapse;font-size:.94rem;min-width:100%}.cl-reading td,.cl-reading th{padding:10px 14px;border:1px solid #dce5eb;text-align:left;vertical-align:top}.cl-reading .table-scroll{overflow-x:auto}.cl-reading details{font-size:.94rem;margin-top:10px}.cl-reading summary{cursor:pointer;color:#2875a7}.cl-reading a{color:#2875a7;text-decoration:underline;text-decoration-color:#bbd8eb;text-underline-offset:4px}.cl-reading ul{list-style:disc;padding-left:24px}.cl-reading .data-note{font-size:.94rem;color:#576f7e}.cl-reading .source-attribution{font-size:.94rem;color:#5c7180;line-height:1.7;padding:20px;background:#f3f8fc;border-radius:10px}.cl-table-wrap{overflow:auto;margin:18px 0}.cl-page table{border-collapse:collapse;width:100%;font-size:.94rem}.cl-page table td,.cl-page table th{text-align:left;padding:12px;border-bottom:1px solid #dce6ed;vertical-align:top}.cl-page table th{background:#f5f9fc;font-weight:600}.cl-page details{border:1px solid #dce6ed;border-radius:8px;padding:14px 18px;margin:12px 0}.cl-page summary{cursor:pointer;font-weight:600}.cl-page details>:not(summary){margin-top:16px}.cl-page a:hover,.cl-treatment-panel a:hover{text-decoration:underline;text-underline-offset:4px}.cl-source-fields{margin:8px 0;font-size:.94rem}.cl-source-fields>div{display:grid;grid-template-columns:minmax(120px,180px) minmax(0,1fr);gap:18px;padding:10px 0;border-bottom:1px solid #edf1f4}.cl-source-fields dt{text-transform:capitalize;color:#647985}.cl-source-fields dd{min-width:0}.cl-source-fields .cl-source-fields>div{display:block}.cl-source-fields .cl-source-fields dt{margin-bottom:5px}.cl-source-array{padding-left:22px;list-style:decimal}.cl-source-array>li{padding:8px 0}.cl-verbatim{white-space:pre-wrap;overflow-wrap:anywhere;line-height:1.65}.cl-more{padding:11px 18px;margin:18px 0;border:1px solid #a6cce6;border-radius:9px;background:#ecf6ff;color:#21648f;font:inherit;cursor:pointer}.cl-check{display:flex;gap:10px;align-items:center;font-size:.94rem;margin:18px 0}.cl-check input{accent-color:#367dad;width:17px;height:17px}.cl-facts{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:20px;padding:22px;background:#f5f9fc;border-radius:10px;margin:24px 0}.cl-facts dt{font-size:.875rem;color:#607786;margin-bottom:8px}.cl-facts dd{font-size:1rem;overflow-wrap:anywhere}.cl-archive-controls{display:grid;grid-template-columns:repeat(auto-fit,minmax(180px,1fr))}.cl-archive-chart{margin:28px 0;padding:22px;border:1px solid #dce6ed;border-radius:10px}.cl-archive-chart svg{width:100%;height:auto;max-height:380px}@media (max-width:650px){.cl-facts{grid-template-columns:1fr}.cl-source-fields>div{display:block}.cl-source-fields dt{margin-bottom:6px}}@media (max-width:760px){.cl-page{padding:20px 20px 44px}.cl-heading,.cl-reader-controls,.cl-subnav{flex-direction:column}.cl-topic-grid{grid-template-columns:1fr}.cl-page-heading{margin-top:26px}.cl-subnav nav{gap:18px}.cl-reading{font-size:1rem}}.cn-freshness{display:flex;flex-wrap:wrap;align-items:baseline;justify-content:space-between;gap:10px 24px;padding:15px 0;border-top:1px solid #dbe6ef;border-bottom:1px solid #dbe6ef;color:#566b7b;font-size:.94rem;line-height:1.6}.cn-freshness strong{color:#364f62;font-weight:600}.cn-coverage a,.cn-freshness a{color:#216997;text-decoration:underline;text-underline-offset:4px}.cn-controls{margin-top:26px}.cn-controls label:last-child{max-width:240px}.cn-feed-bar{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:8px 20px;margin-bottom:8px}.cn-feed-bar .cl-filter-row{margin:0}.cn-feed-bar button{min-height:44px}.cn-feed{list-style:none;padding:0;margin:20px 0;border-top:1px solid #dbe6ef}.cn-entry{display:grid;grid-template-columns:162px minmax(0,1fr);gap:36px;padding:30px 0;border-bottom:1px solid #dbe6ef}.cn-date{display:flex;flex-direction:column;gap:8px}.cn-date time{color:#255d82;font-size:1rem;font-weight:600}.cn-date span{color:#627684;font-size:.875rem;line-height:1.5}.cn-meta{display:flex;flex-wrap:wrap;align-items:center;gap:8px 12px;font-size:.875rem;color:#566b79}.cn-kind{background:#edf6fc;color:#236189;border:1px solid #d7e7f3;padding:3px 9px;border-radius:5px}.cn-kind-results{background:#f1f2fb;color:#525f96;border-color:#e0e3f3}.cn-kind-safety{background:#fff6e8;color:#78561c;border-color:#efddbd}.cn-entry h2{font:500 clamp(1.18rem,2vw,1.45rem) /1.4 var(--font-site-serif);color:#253b4a;margin:12px 0 10px;overflow-wrap:anywhere}.cn-entry h2 a:hover{color:#276b99;text-decoration:underline;text-underline-offset:4px;text-decoration-color:#9ec5df}.cn-detail{color:#5a6d7a;font-size:1rem;line-height:1.6;margin-bottom:9px;overflow-wrap:anywhere}.cn-warning{color:#7a4319;border-left:3px solid #d7a96d;padding:8px 12px;background:#fff8ed;margin-top:12px;font-size:.94rem}.cn-links{display:flex;gap:14px 25px;flex-wrap:wrap;margin-top:15px;color:#246f9f;font-size:.94rem}.cn-links a{padding:6px 0;text-decoration:underline;text-decoration-color:#bed9eb;text-underline-offset:5px}.cn-links a:hover{text-decoration-color:currentColor}.cn-empty button,.cn-more{cursor:pointer;padding:12px 18px;border-radius:10px;border:1px solid #9cc6e2;background:#edf7ff;color:#245f89;font:inherit;box-shadow:0 3px 0 #c4e0f1}.cn-empty button:hover,.cn-more:hover{background:#e1f1ff;border-color:#6daed9}.cn-more{display:block;margin:24px auto}.cn-search-note{text-align:center;margin-top:20px}.cn-coverage{border:1px solid #dbe6ef;border-radius:10px;padding:18px 22px;margin-top:36px;color:#506674}.cn-coverage summary{cursor:pointer;font-size:1rem;color:#304e63}.cn-coverage p{font-size:1rem;line-height:1.7;margin-top:16px}.cn-empty{padding:40px 16px;text-align:center}.cn-empty h2{font:500 1.5rem/1.4 var(--font-site-serif);margin-bottom:12px}.cn-empty p{margin-bottom:18px}.cn-inline-button{cursor:pointer;text-decoration:underline}.cn-controls :disabled,.cn-feed-bar :disabled{opacity:.65;cursor:wait}.cn-coverage summary:focus-visible,.cn-entry a:focus-visible,.cn-feed-bar button:focus-visible{outline:2px solid #397aa4;outline-offset:5px;border-radius:3px}#news-coverage,#posted-results,.cl-next details[id]{scroll-margin-top:110px}.cx-toolbar{flex-wrap:wrap;gap:12px 20px}@media (max-width:680px){.cn-page .cl-subnav{gap:14px;padding-bottom:14px}.cn-page .cl-subnav nav{flex-wrap:nowrap;overflow-x:auto;padding-bottom:8px;gap:20px}.cn-page .cl-subnav nav a{white-space:nowrap;padding:4px 0}.cn-page .cl-page-heading{margin:18px 0}.cn-page .cl-page-heading h1{margin-bottom:0}.cn-page .cl-eyebrow{margin-bottom:8px}.cn-freshness{padding:12px 0;gap:6px}.cn-controls{display:grid;grid-template-columns:minmax(0,1fr) 130px;gap:14px;margin-top:18px}.cn-controls label:last-child{max-width:none}.cn-entry{grid-template-columns:minmax(0,1fr);gap:14px;padding:25px 0}.cn-date{flex-direction:row;flex-wrap:wrap;align-items:baseline;gap:6px 12px}.cn-feed-bar>p{width:100%;margin-top:8px}.cn-links{gap:8px 20px}}@media (max-width:350px){.cn-controls{grid-template-columns:minmax(0,1fr)}}.cs-page .cl-page-heading{margin-bottom:20px}.cs-page .cl-page-heading h1{font-size:clamp(2rem,4vw,3rem)}.cs-measures{display:flex;gap:8px;flex-wrap:wrap;border-bottom:1px solid #dce6ee;padding-bottom:20px;margin-bottom:24px}.cs-measures a{padding:10px 14px;border:1px solid transparent;border-radius:8px;color:#4b6273;font-size:.98rem}.cs-measures a[aria-current]{color:#205f8a;background:#edf7ff;border-color:#b9d7ec}.cs-measures a:hover{text-decoration:underline;text-underline-offset:4px}.cs-workspace{display:grid;grid-template-columns:250px minmax(0,1fr);gap:32px;align-items:start}.cs-controls{display:grid;gap:17px}.cs-field{display:grid;gap:7px}.cs-controls label{color:#344f60;font-size:.9rem}.cs-controls select{width:100%;min-width:0;min-height:44px;background:#fff;border:1px solid #b6cbd9;border-radius:8px;padding:10px 28px 10px 11px;font:inherit;color:#253f51}.cs-controls p{font-size:.84rem;line-height:1.6;color:#5a7180}.cs-advanced summary{min-height:44px;color:#315f7f;cursor:pointer;font-size:.94rem}.cs-page .cs-advanced{border:0;padding:0;margin:0}.cs-page .cs-advanced summary{font-weight:500;padding:10px 0}.cs-advanced>div{display:grid;gap:17px}.cs-results{min-width:0;border:1px solid #d7e5ee;border-radius:16px;padding:26px 30px;background:#fff}.cs-results h2{font:500 clamp(1.6rem,2.5vw,2.15rem) /1.25 var(--font-site-serif);margin:8px 0 12px;color:#263f50}.cs-description{font-size:1rem;line-height:1.65;color:#526977}.cs-horizon{margin-top:14px;color:#285f83;font-weight:600}.cs-population{margin:18px 0 6px;padding-top:16px;border-top:1px solid #e0e9f0;font-size:.9rem;color:#536b7b;line-height:1.6}.cs-estimate{padding:24px 0;display:flex;flex-direction:column;gap:8px}.cs-estimate strong{font:500 clamp(2.4rem,5vw,4rem) /1.1 var(--font-site-serif);color:#367eac}.cs-estimate span{font-size:1.1rem;color:#38566c}.cs-estimate p{font-size:.88rem;color:#5a7180}.cs-plot{margin:15px 0 0}.cs-plot svg{width:100%;height:auto;overflow:visible}.cs-plot text{font:13px var(--font-site-sans);fill:#536b7b}.cs-plot figcaption{display:flex;gap:12px 20px;flex-wrap:wrap;font-size:.84rem;line-height:1.5;color:#566e7f;margin:8px 0 20px}.cs-key:before{content:"";display:inline-block;width:22px;border-top:3px solid #367eac;margin-right:8px;vertical-align:middle}.cs-modeled:before{border-color:#8b6fb2;border-top-style:dashed}.cs-actions{display:flex;align-items:center;flex-wrap:wrap;gap:14px 22px;font-size:.94rem;color:#26688f}.cs-actions button,.cs-unavailable button{cursor:pointer;font:inherit;color:#215c86;background:#edf7ff;border:1px solid #a4cbe5;border-radius:9px;padding:10px 14px;min-height:44px;box-shadow:0 2px 0 #cee5f4}.cs-actions a{text-decoration:underline;text-underline-offset:4px;min-height:44px;display:inline-flex;align-items:center}.cs-context{font-size:.87rem;line-height:1.65;color:#526d7e;border-top:1px solid #dce7ef;margin-top:22px;padding-top:18px}.cs-unavailable{padding:25px 0;color:#685b43;line-height:1.6}.cs-unavailable h3{font-size:1.3rem}.cs-unavailable button{margin-top:15px}.cs-source-values{margin-top:44px;scroll-margin-top:100px}.cs-source-values h2{font:500 1.8rem var(--font-site-serif);margin-bottom:12px}.cs-source-values>p{color:#586f7e;line-height:1.7;margin-bottom:20px}.cs-source-values table{width:100%;min-width:720px;border-collapse:collapse;text-align:left;font-size:.9rem}.cs-source-values td,.cs-source-values th{padding:12px;border-bottom:1px solid #dce6ee;white-space:nowrap}.cs-source-values th{font-weight:600;color:#304e62}.cs-source-values caption{text-align:left;padding:10px;color:#5d7483;white-space:normal}.cs-source-values .cl-table-wrap{overflow-x:auto}.cs-provenance{border-top:1px solid #dce7ef;padding-top:20px;margin-top:30px;color:#506b7c}.cs-provenance summary{cursor:pointer;min-height:44px;font-size:1.05rem;color:#2b516a}.cs-provenance p{margin:14px 0;font-size:.94rem;line-height:1.7}.cs-provenance code{overflow-wrap:anywhere;font-size:.82rem}.cs-page :is(a,button,select,summary,[tabindex]):focus-visible{outline:2px solid #367eac;outline-offset:4px}@media (max-width:760px){.cs-page .cl-subnav{gap:12px;padding-bottom:12px}.cs-page .cl-subnav nav{flex-wrap:nowrap;overflow-x:auto;width:100%;gap:20px;padding-bottom:8px}.cs-page .cl-subnav nav a{flex-shrink:0}.cs-page .cl-page-heading{padding-top:0;margin-top:18px}.cs-workspace{grid-template-columns:1fr;gap:20px}.cs-controls{grid-template-columns:1fr 1fr;gap:12px}.cs-advanced,.cs-cancer-field,.cs-controls p{grid-column:1/-1}.cs-advanced>div{grid-template-columns:1fr 1fr}.cs-controls p{margin:0}.cs-results{padding:20px 16px}.cs-measures{flex-wrap:nowrap;overflow-x:auto;padding-bottom:12px;margin-bottom:18px}.cs-measures a{flex-shrink:0}.cs-page .cl-page-heading{margin-bottom:16px}.cs-plot{overflow-x:auto}.cs-plot svg{min-width:460px}.cs-results h2{font-size:1.5rem}}.cp-page{max-width:1200px}.cp-invitation{display:flex;align-items:center;justify-content:space-between;flex-wrap:wrap;gap:24px;margin-top:36px;padding:clamp(20px,3vw,32px);border:1px solid #d3e1e9;border-radius:18px;background:#f4faff}.cancer-site .cp-invitation h2{font-size:1.6rem;margin:0 0 10px}.cancer-site .cp-invitation p{font-size:1rem;color:var(--ce-muted);max-width:42ch;margin:0}.cp-invitation-action{display:grid;gap:10px;justify-items:center}.cp-invitation-action>span{font-size:.875rem;color:var(--ce-muted)}@media (max-width:760px){.cp-invitation-action,.cp-invitation-action .cp-primary{width:100%}}@media print{.cp-invitation{display:none!important}}.cp-page .cl-page-heading{max-width:850px}.cp-page .cl-page-heading>p:last-child{max-width:740px}.cp-intro,.cp-referral,.cp-study-start{display:grid;grid-template-columns:1fr 1fr;gap:clamp(28px,5vw,76px)}.cp-intro{align-items:start;margin:28px 0 64px}.cp-start{display:grid;justify-items:start;align-content:start;gap:18px}.cancer-site .cp-primary,.cancer-site .cp-secondary{display:inline-flex;align-items:center;justify-content:center;min-height:46px;padding:12px 20px;border:1px solid #9cc9e5;border-radius:12px;background:#eaf6ff;color:#184c73;font:inherit;font-weight:600;text-align:center;line-height:1.4}.cancer-site .cp-primary{box-shadow:0 3px 0 #b8d9ec}.cancer-site .cp-primary:hover,.cancer-site .cp-secondary:hover{background:#ddf0ff;color:#103e5e}.cancer-site .cp-secondary{background:white}.cancer-site .cp-kicker{color:var(--ce-blue);font-size:14px;font-weight:600;margin-bottom:12px}.cancer-site .cp-small{font-size:14px;line-height:1.6;color:var(--ce-muted)}.cp-prompts{border:1px solid #d7e7f0;border-radius:20px;background:#f4faff;padding:clamp(22px,3vw,36px)}.cp-prompts ol{list-style:decimal;padding-left:22px;margin:24px 0 0}.cp-prompts li{padding-left:6px;margin-top:20px}.cp-prompts li::marker{color:var(--ce-blue)}.cp-prompts span,.cp-prompts strong{display:block}.cp-prompts span{margin-top:4px;color:var(--ce-muted)}.cp-referral,.cp-study-start{border-top:1px solid var(--ce-line);padding-top:40px;margin-top:44px}.cp-referral p,.cp-study-start p{margin-top:16px}.cp-study-links{display:grid;gap:12px}.cp-study-links a{display:grid;gap:6px;padding:16px 20px;border:1px solid var(--ce-line);border-radius:14px}.cp-study-links a:hover{border-color:#91bdd8;background:#f4faff}.cp-study-links a>span{font-size:14px;color:var(--ce-muted)}.cp-study-links strong{display:flex;justify-content:space-between;gap:16px;color:var(--ce-blue)}.cp-share{display:grid;align-content:start;justify-items:start;gap:12px;min-width:0}.cp-share input{width:100%;min-width:0;border:1px solid #bdcbd4;border-radius:8px;padding:12px;font:inherit;background:white}.cp-share p{margin:0}.cp-comparison{margin-top:32px;border:1px solid #d3e1e9;border-radius:18px;overflow:hidden}.cancer-site section.cp-comparison{scroll-margin-top:7rem}.cancer-site .cp-comparison-heading>p:not(.cp-kicker),.cancer-site .cp-login-strip>div>p{font-size:1rem}.cp-comparison-heading,.cp-question{padding:26px}.cp-comparison-heading{background:#f4faff}.cp-comparison-heading a,.cp-comparison-heading p{margin-top:12px}.cp-comparison-heading a{display:inline-block;font-size:14px}.cp-statements{padding:0 26px}.cp-statement{min-width:0;border:0;padding:24px 0;margin:0}.cp-statement+.cp-statement{border-top:1px solid var(--ce-line)}.cp-statement legend{float:left;width:100%;padding:0;margin-bottom:14px;font-size:16px}.cp-choices{display:flex;flex-wrap:wrap;gap:10px;clear:both}.cp-choices label{display:flex;align-items:center;gap:8px;padding:10px 12px;min-height:44px;border:1px solid #bccbd4;border-radius:10px;cursor:pointer;font-size:14px}.cp-choices label:has(input:checked){background:#eaf6ff;border-color:#4f8caf;color:#184c73}.cp-choices input{width:16px;height:16px;margin:0;accent-color:#2a6e9e}.cancer-site .cp-boundary{margin:0 26px;padding:18px 0;font-size:14px;color:var(--ce-muted)}.cancer-site .cp-boundary,.cp-question{border-top:1px solid var(--ce-line)}.cp-copy-fallback,.cp-question>label{display:block;font-weight:600}.cp-question textarea{display:block;width:100%;border:1px solid #bdcbd4;border-radius:10px;background:white;padding:12px;font:inherit;font-weight:400;font-size:16px;line-height:1.5;resize:vertical;margin:12px 0}.cp-question textarea::placeholder{color:#64717b}.cp-actions{display:flex;flex-wrap:wrap;align-items:center;gap:18px;margin-top:18px}.cp-reset{min-height:44px;padding:8px;border:0;background:none;color:var(--ce-muted);text-decoration:underline;text-underline-offset:4px}.cancer-site .cp-status:not(:empty){margin-top:12px}.cp-login-strip{display:grid;gap:16px;justify-items:start;padding:24px 26px;background:#f4faff;border-top:1px solid #d3e1e9}.cp-login-strip p{margin-top:6px}.cp-login-strip .cp-small{margin:0}@media (max-width:760px){.cancer-site section.cp-comparison{scroll-margin-top:9rem}.cp-intro,.cp-referral,.cp-study-start{grid-template-columns:1fr;gap:28px}.cp-intro{margin-bottom:40px}.cp-comparison-heading,.cp-login-strip,.cp-question{padding:20px}.cp-statements{padding-inline:20px}.cancer-site .cp-boundary{margin-inline:20px}.cp-choices{display:grid}.cp-choices label{width:fit-content}}